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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone replacement does not improve ejaculatory dysfunction
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<blockquote data-quote="Nelson Vergel" data-source="post: 21314" data-attributes="member: 3"><p>J Clin Endocrinol Metab. 2015 Jul 9:jc20144434. [Epub ahead of print]</p><p></p><p><strong>Testosterone Replacement in Androgen-Deficient Men With Ejaculatory Dysfunction: A Randomized Controlled Trial.</strong></p><p></p><p>Paduch DA1, Polzer PK1, Ni X1, Basaria S1.</p><p></p><p></p><p></p><p>Abstract</p><p></p><p>CONTEXT:</p><p></p><p>Low T levels have been associated with ejaculatory dysfunction (EjD) in cross-sectional studies; however, the efficacy of T replacement in improving EjD has not been studied in a randomized controlled trial.</p><p></p><p>OBJECTIVE:</p><p>To evaluate the efficacy of T replacement in androgen-deficient men with EjD.</p><p></p><p>DESIGN:</p><p>A multicenter, double-blind, randomized, placebo-controlled, 16-week trial with T solution 2% versus placebo.</p><p></p><p>SETTING:</p><p>Medical centers in the United States, Canada, and Mexico.</p><p></p><p>PATIENTS OR OTHER PARTICIPANTS:</p><p><strong>Seventy-six men with one or more EjD symptoms, including delayed ejaculation, anejaculation, reduced ejaculate volume, and/or reduced force of ejaculation,</strong> and two total T levels <300 ng/dL (<10.41 nmol/L) measured with liquid chromatography tandem mass spectrometry.</p><p></p><p>INTERVENTIONS:</p><p>Sixty milligrams of T solution 2% or placebo applied to the axillae for 16 weeks.</p><p></p><p>MAIN OUTCOME MEASURES:</p><p>The primary outcome was a change in the score of the three-item Male Sexual Health Questionnaire-Ejaculatory Dysfunction-Short Form (MSHQ-EjD-SF); secondary outcomes included measured ejaculate volume, scores of the bother/satisfaction item of the MSHQ-EjD-SF, the orgasmic function domain of the International Index of Erectile Function Questionnaire, and the sexual activity log.</p><p></p><p>RESULTS:</p><p>Seventy-six participants were randomized; 66 completed the study. Baseline demographic and clinical characteristics were comparable between the treatment arms. T replacement improved the MSHQ-EjD-SF score (mean score change, +3.1); however, this effect was not statistically different from placebo (mean score change, +2.5; P = .596). No differences were seen in any of the secondary outcomes or frequency of adverse events.</p><p></p><p>CONCLUSION:</p><p>T replacement was not associated with significant improvement in EjD in androgen-deficient men.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 21314, member: 3"] J Clin Endocrinol Metab. 2015 Jul 9:jc20144434. [Epub ahead of print] [B]Testosterone Replacement in Androgen-Deficient Men With Ejaculatory Dysfunction: A Randomized Controlled Trial.[/B] Paduch DA1, Polzer PK1, Ni X1, Basaria S1. Abstract CONTEXT: Low T levels have been associated with ejaculatory dysfunction (EjD) in cross-sectional studies; however, the efficacy of T replacement in improving EjD has not been studied in a randomized controlled trial. OBJECTIVE: To evaluate the efficacy of T replacement in androgen-deficient men with EjD. DESIGN: A multicenter, double-blind, randomized, placebo-controlled, 16-week trial with T solution 2% versus placebo. SETTING: Medical centers in the United States, Canada, and Mexico. PATIENTS OR OTHER PARTICIPANTS: [B]Seventy-six men with one or more EjD symptoms, including delayed ejaculation, anejaculation, reduced ejaculate volume, and/or reduced force of ejaculation,[/B] and two total T levels <300 ng/dL (<10.41 nmol/L) measured with liquid chromatography tandem mass spectrometry. INTERVENTIONS: Sixty milligrams of T solution 2% or placebo applied to the axillae for 16 weeks. MAIN OUTCOME MEASURES: The primary outcome was a change in the score of the three-item Male Sexual Health Questionnaire-Ejaculatory Dysfunction-Short Form (MSHQ-EjD-SF); secondary outcomes included measured ejaculate volume, scores of the bother/satisfaction item of the MSHQ-EjD-SF, the orgasmic function domain of the International Index of Erectile Function Questionnaire, and the sexual activity log. RESULTS: Seventy-six participants were randomized; 66 completed the study. Baseline demographic and clinical characteristics were comparable between the treatment arms. T replacement improved the MSHQ-EjD-SF score (mean score change, +3.1); however, this effect was not statistically different from placebo (mean score change, +2.5; P = .596). No differences were seen in any of the secondary outcomes or frequency of adverse events. CONCLUSION: T replacement was not associated with significant improvement in EjD in androgen-deficient men. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone replacement does not improve ejaculatory dysfunction
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