ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Testosterone Recovery Profiles After Short-Term ADT
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 223325" data-attributes="member: 13851"><p><strong>Testosterone (T) Recovery Profiles After Short-Term Androgen Deprivation Therapy (ADT) (2022)</strong></p><p><em>JFlores Martinez, BNascimento, NBenfante, ESchofield, JPMulhall</em></p><p></p><p></p><p><strong>Introduction</strong></p><p><strong></strong></p><p><strong><em>ADT plays a major role in several scenarios for men with prostate cancer. T recovery after ADT cessation may be incomplete with 10% of men estimated to suffer persistent castrate levels after long-term ADT.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Objective</strong></p><p><strong></strong></p><p><strong><em>The objective of this study was to evaluate T recovery after short courses of ADT.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Methods</strong></p><p><strong></strong></p><p><strong><em>The study population included men treated with ≤6 months of ADT in association with radiation therapy (RT). Early morning T levels were collected at baseline and periodically after ADT cessation. T recovery after ADT cessation was analyzed in 2 ways: improvement to non-castrated level (T ≥50 ng/dL), and recovery to normal (T ≥ 300 ng/dL). Recovery rates and median survival time were estimated using Kaplan-Meier statistics and predictors were analyzed using Cox proportional hazard ratios.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Results</strong></p><p><strong></strong></p><p><strong><em>88 men with a mean age of 68 ± 8 years at the time of ADT were analyzed. The median duration of ADT was 3.1 months; 56% had an ADT duration between 1-3 months and 44% between 4-6 months. The mean pre-ADT T level was 390 ± 158 ng/dL. After cessation of ADT, the median time to non- castrate levels was 9.3 (IQR = 6.3 – 18.5) months and 15.8 (IQR = 8.3 - 33.8) `months for recovery to T ≥300 ng/dL. Higher baseline T levels (T > 400 ng/dL) were associated with faster recovery to normal T level (HR = 1.80, 95% CI = 1.09 – 2.95), but not to non-castrated level. Neither age > 65 years, prevalent diabetes, nor ADT duration of 4-6 months vs ≤ 3 months were significantly associated with a slower T recovery.</em></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Conclusions</strong></p><p><strong></strong></p><p><strong><em>Most of our patients remained with low T levels one year after the cessation of ADT. Higher baseline T was associated with faster T recovery to normal (T ≥ 300 ng/dL).</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 223325, member: 13851"] [B]Testosterone (T) Recovery Profiles After Short-Term Androgen Deprivation Therapy (ADT) (2022)[/B] [I]JFlores Martinez, BNascimento, NBenfante, ESchofield, JPMulhall[/I] [B]Introduction [I]ADT plays a major role in several scenarios for men with prostate cancer. T recovery after ADT cessation may be incomplete with 10% of men estimated to suffer persistent castrate levels after long-term ADT.[/I] Objective [I]The objective of this study was to evaluate T recovery after short courses of ADT.[/I] Methods [I]The study population included men treated with ≤6 months of ADT in association with radiation therapy (RT). Early morning T levels were collected at baseline and periodically after ADT cessation. T recovery after ADT cessation was analyzed in 2 ways: improvement to non-castrated level (T ≥50 ng/dL), and recovery to normal (T ≥ 300 ng/dL). Recovery rates and median survival time were estimated using Kaplan-Meier statistics and predictors were analyzed using Cox proportional hazard ratios.[/I] Results [I]88 men with a mean age of 68 ± 8 years at the time of ADT were analyzed. The median duration of ADT was 3.1 months; 56% had an ADT duration between 1-3 months and 44% between 4-6 months. The mean pre-ADT T level was 390 ± 158 ng/dL. After cessation of ADT, the median time to non- castrate levels was 9.3 (IQR = 6.3 – 18.5) months and 15.8 (IQR = 8.3 - 33.8) `months for recovery to T ≥300 ng/dL. Higher baseline T levels (T > 400 ng/dL) were associated with faster recovery to normal T level (HR = 1.80, 95% CI = 1.09 – 2.95), but not to non-castrated level. Neither age > 65 years, prevalent diabetes, nor ADT duration of 4-6 months vs ≤ 3 months were significantly associated with a slower T recovery.[/I] Conclusions [I]Most of our patients remained with low T levels one year after the cessation of ADT. Higher baseline T was associated with faster T recovery to normal (T ≥ 300 ng/dL).[/I][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Prostate Related Issues
Testosterone Recovery Profiles After Short-Term ADT
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top