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Nov. 2020 I finished radiation treatment (RT) for prostate cancer (Gleason 6
Stage: Stg IIA T: T1c N: N0 M: M0). I had previously been been on testosterone replacement therapy (TRT) and over a period of 5 years my PSA increased to 11. I stopped TRT in Jun 2020 and PSA dropped to 2. After RT, the PSA was <0.1 or unmeasurable but I was miserable with my free testosterone level at 20. I recently resumed TRT and my first blood test shows PSA is at 2 again. I wonder if 2 is going to be my new baseline or does that indicate the cancer is active again.

[QUOTE="D0UG, post: 212027, member: 42784"] Nov. 2020 I finished radiation treatment (RT) for prostate cancer (Gleason 6 Stage: Stg IIA T: T1c N: N0 M: M0). I had previously been been on testosterone replacement therapy (TRT) and over a period of 5 years my PSA increased to 11. I stopped TRT in Jun 2020 and PSA dropped to 2. After RT, the PSA was <0.1 or unmeasurable but I was miserable with my free testosterone level at 20. I recently resumed TRT and my first blood test shows PSA is at 2 again. I wonder if 2 is going to be my new baseline or does that indicate the cancer is active again. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038