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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Production by Stimulating Leydig Cells
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<blockquote data-quote="Jinzang" data-source="post: 174321" data-attributes="member: 12925"><p>The biochemistry is over my head, but this rat study showed that testosterone production can be increased by stimulating the production of a "cholesterol-binding translocator protein (TSPO)." The compound used was FGIN-1-27. The <a href="https://academic.oup.com/biolreprod/article-abstract/102/2/489/5556302" target="_blank">abstract</a> says:</p><p></p><p>"Both exogenous T and FGIN-1-27 increased serum T levels. With exogenous T, serum LH and Leydig cell T formation were suppressed, and intratesticular T was reduced to below the concentration required to maintain spermatogenesis quantitatively. In contrast, FGIN-1-27 stimulated Leydig cell T formation, resulting in increased serum T without reductions in intratesticular T concentrations or in testicular sperm numbers. FGIN-1-27 also significantly increased serum and intratesticular T levels in rats made LH-deficient by treatment with the gonadotropin-releasing hormone antagonist cetrorelix. These results point to a possible approach to increasing serum T without negative effects on spermatogenesis, based upon stimulating T production by the Leydig cells themselves rather than administering T exogenously."</p></blockquote><p></p>
[QUOTE="Jinzang, post: 174321, member: 12925"] The biochemistry is over my head, but this rat study showed that testosterone production can be increased by stimulating the production of a "cholesterol-binding translocator protein (TSPO)." The compound used was FGIN-1-27. The [URL='https://academic.oup.com/biolreprod/article-abstract/102/2/489/5556302']abstract[/URL] says: "Both exogenous T and FGIN-1-27 increased serum T levels. With exogenous T, serum LH and Leydig cell T formation were suppressed, and intratesticular T was reduced to below the concentration required to maintain spermatogenesis quantitatively. In contrast, FGIN-1-27 stimulated Leydig cell T formation, resulting in increased serum T without reductions in intratesticular T concentrations or in testicular sperm numbers. FGIN-1-27 also significantly increased serum and intratesticular T levels in rats made LH-deficient by treatment with the gonadotropin-releasing hormone antagonist cetrorelix. These results point to a possible approach to increasing serum T without negative effects on spermatogenesis, based upon stimulating T production by the Leydig cells themselves rather than administering T exogenously." [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Production by Stimulating Leydig Cells
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