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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Pellet Dose Comparison
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<blockquote data-quote="Nelson Vergel" data-source="post: 9166" data-attributes="member: 3"><p>It depends on the pellet. Testopel, the only FDA approved pellet in the US, contains only 75 mg per pellet. Compounding pharmacies can legally make pellets up to 200 mg of testosterone per pellet. I am not sure which one you are using.</p><p></p><p>12 Testopel pellets were able to keep my total testosterone over 500 ng/dL for 10 weeks or so. The manufacturer swears it lasts longer than that, with promises of 3-4 months. They use 350 ng/dL as the cut off point to decide when to insert again, but we know that is not enough for most of us.</p><p></p><p>In <a href="http://www.ncbi.nlm.nih.gov/pubmed/2115044" target="_blank">this study</a> using a 200 mg pellet, they found that "the estimated rate of release of testosterone from one pellet was 1.5 (95% confidence limits 1.3-1.6) mg/day as determined from direct measurement of residue in pellets recovered after extrusion and confirmed independently from percent absorbed-time plots."</p><p></p><p>A healthy man can produce 4-6 mg per day of testosterone. </p><p></p><p>Here is a graph that shows the blood level of testosterone (average) in 14 men who were administered 6 - 200 mg pellets (total of 1200 mg).</p><p></p><p></p><p>Since the graph uses metric units (nmol/l), we need to convert 500 ng/dL into nmol/l by dividing 500 by 28.82 = 17.4 nmol/l</p><p></p><p>This level was achieved in about 140 days (or 20 weeks or 5 months) after insertion of the 6 -200 mg pellets</p><p></p><p>Testopel has 75 mg of testosterone. For 1200 mg of total T dose, 18 Testopel pellets would be needed. As a guess estimate, 9-10 Testopel pellets could be sufficient to keep T levels above 500 ng/dL for 10 weeks (based on an assumption that a constant 1.5 mg per pellet would be released, which may be different for a smaller pellet like Testopel).</p><p></p><p></p><p>[ATTACH]830[/ATTACH]</p><p></p><p></p><p></p><p><a href="http://www.hormonebalance.org/images/documents/Pellets%20Pharma%20Clin%20En%2096%20Jockenhovel.pdf" target="_blank">http://www.hormonebalance.org/images/documents/Pellets Pharma Clin En 96 Jockenhovel.pdf</a></p><p></p><p>More information on testosterone pellets can be found here:</p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?1487-Testosterone-Replacement-Treatment-Options" target="_blank">Testosterone Replacement Treatment Options</a></strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 9166, member: 3"] It depends on the pellet. Testopel, the only FDA approved pellet in the US, contains only 75 mg per pellet. Compounding pharmacies can legally make pellets up to 200 mg of testosterone per pellet. I am not sure which one you are using. 12 Testopel pellets were able to keep my total testosterone over 500 ng/dL for 10 weeks or so. The manufacturer swears it lasts longer than that, with promises of 3-4 months. They use 350 ng/dL as the cut off point to decide when to insert again, but we know that is not enough for most of us. In [URL="http://www.ncbi.nlm.nih.gov/pubmed/2115044"]this study[/URL] using a 200 mg pellet, they found that "the estimated rate of release of testosterone from one pellet was 1.5 (95% confidence limits 1.3-1.6) mg/day as determined from direct measurement of residue in pellets recovered after extrusion and confirmed independently from percent absorbed-time plots." A healthy man can produce 4-6 mg per day of testosterone. Here is a graph that shows the blood level of testosterone (average) in 14 men who were administered 6 - 200 mg pellets (total of 1200 mg). Since the graph uses metric units (nmol/l), we need to convert 500 ng/dL into nmol/l by dividing 500 by 28.82 = 17.4 nmol/l This level was achieved in about 140 days (or 20 weeks or 5 months) after insertion of the 6 -200 mg pellets Testopel has 75 mg of testosterone. For 1200 mg of total T dose, 18 Testopel pellets would be needed. As a guess estimate, 9-10 Testopel pellets could be sufficient to keep T levels above 500 ng/dL for 10 weeks (based on an assumption that a constant 1.5 mg per pellet would be released, which may be different for a smaller pellet like Testopel). [ATTACH=CONFIG]830[/ATTACH] [URL]http://www.hormonebalance.org/images/documents/Pellets%20Pharma%20Clin%20En%2096%20Jockenhovel.pdf[/URL] More information on testosterone pellets can be found here: [b][URL="https://www.excelmale.com/forum/showthread.php?1487-Testosterone-Replacement-Treatment-Options"]Testosterone Replacement Treatment Options[/URL][/b] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Testosterone Pellet Dose Comparison
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