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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone meets albumin – the molecular mechanism of sex hormone transport by serum albumins†
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<blockquote data-quote="madman" data-source="post: 147032" data-attributes="member: 13851"><p><span style="font-size: 26px"><strong>Testosterone Discovery May Explain Low Levels in Men With Diabetes</strong></span></p><p><strong><span style="color: rgb(184, 49, 47)">March 27 2019</span></strong></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)"><a href="https://newsroom.uvahealth.com/2019/03/27/testosterone-discovery-may-explain-low-levels-in-men-with-diabetes/" target="_blank">https://newsroom.uvahealth.com/2019/03/27/testosterone-discovery-may-explain-low-levels-in-men-with-diabetes/</a></span></strong></p><p></p><p></p><p></p><p></p><p><span style="font-size: 22px"><strong>Potential Answers About Low T</strong></span></p><p>The discovery represents a collaboration of Minor’s lab, in UVA’s Department of Molecular Physiology and Biological Physics, with that of David Hage, PhD, of the Department of Chemistry at the University of Nebraska–Lincoln. Together, they developed the first 3D structure of serum albumin bound to a sex hormone with results of binding studies, which led to some unexpected findings.</p><p></p><p>Using an approach known as X-ray crystallography, the researchers were able to inspect the complex in unbelievable detail. But this was no easy task: First they had to capture the pairing inside a lab-made crystal – a tremendous challenge – and then they could bombard it with a stream of powerful X-rays. By tracking how the X-rays diffracted, they could determine the shape of something far too small for even the most powerful light microscopes to see.</p><p></p><p><strong>What they found defied expectations:</strong> <span style="color: rgb(184, 49, 47)"><strong>Testosterone was not bound in its previously predicted binding site but rather in </strong></span><span style="color: rgb(44, 130, 201)"><strong>two other sites</strong></span><span style="color: rgb(184, 49, 47)"><strong>, both with an </strong></span><span style="color: rgb(44, 130, 201)"><strong>affinity for fatty acids, various metabolites and certain drugs. </strong></span><strong>That suggests that <span style="color: rgb(184, 49, 47)">testosterone faces strong competition for transport inside the body – </span><span style="color: rgb(44, 130, 201)">important information for doctors not just when prescribing existing treatments but also when looking for new treatments.</span> <span style="color: rgb(184, 49, 47)">(Serum albumin, for example, is an important carrier of cancer drugs.)</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 147032, member: 13851"] [SIZE=26px][B]Testosterone Discovery May Explain Low Levels in Men With Diabetes[/B][/SIZE] [B][COLOR=rgb(184, 49, 47)]March 27 2019[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)][URL]https://newsroom.uvahealth.com/2019/03/27/testosterone-discovery-may-explain-low-levels-in-men-with-diabetes/[/URL][/COLOR][/B] [SIZE=22px][B]Potential Answers About Low T[/B][/SIZE] The discovery represents a collaboration of Minor’s lab, in UVA’s Department of Molecular Physiology and Biological Physics, with that of David Hage, PhD, of the Department of Chemistry at the University of Nebraska–Lincoln. Together, they developed the first 3D structure of serum albumin bound to a sex hormone with results of binding studies, which led to some unexpected findings. Using an approach known as X-ray crystallography, the researchers were able to inspect the complex in unbelievable detail. But this was no easy task: First they had to capture the pairing inside a lab-made crystal – a tremendous challenge – and then they could bombard it with a stream of powerful X-rays. By tracking how the X-rays diffracted, they could determine the shape of something far too small for even the most powerful light microscopes to see. [B]What they found defied expectations:[/B] [COLOR=rgb(184, 49, 47)][B]Testosterone was not bound in its previously predicted binding site but rather in [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]two other sites[/B][/COLOR][COLOR=rgb(184, 49, 47)][B], both with an [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]affinity for fatty acids, various metabolites and certain drugs. [/B][/COLOR][B]That suggests that [COLOR=rgb(184, 49, 47)]testosterone faces strong competition for transport inside the body – [/COLOR][COLOR=rgb(44, 130, 201)]important information for doctors not just when prescribing existing treatments but also when looking for new treatments.[/COLOR] [COLOR=rgb(184, 49, 47)](Serum albumin, for example, is an important carrier of cancer drugs.)[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone meets albumin – the molecular mechanism of sex hormone transport by serum albumins†
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