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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging
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<blockquote data-quote="madman" data-source="post: 146806" data-attributes="member: 13851"><p><strong>Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings </strong></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Fereshteh Farajdokht, Mehdi Farhoudi, Alireza Majdi, Masumeh Zamanlu, Saeed Sadigh-Eteghad, Shabnam Vahedi, Javad Mahmoudi*</span></strong></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong><span style="color: rgb(184, 49, 47)">Abstract</span></strong></p><p>Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. <span style="color: rgb(184, 49, 47)"><strong>Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging.</strong></span> <span style="color: rgb(41, 105, 176)"><strong>TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death.</strong></span> Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusion</strong> </p><p>Based on above, <span style="color: rgb(184, 49, 47)"><strong>TES neuroprotection against stroke in aging appears to be mediated by several mechanisms</strong></span> including <span style="color: rgb(44, 130, 201)"><strong>inhibition of production of oxidant molecules, enhancing the enzymatic antioxidant capacity of the brain, activation of PI3K/AKT pathway and enhancing cell survival, inhibition of pro-apoptotic protein through AR dependent MAPK/ERK pathway, as well as improvement of brain neuronal and BBB integrities.</strong></span> <strong>These mechanisms may propose future therapeutic strategies to improve the quality of life and decrease androgen-related health problems in the aging population. </strong></p></blockquote><p></p>
[QUOTE="madman, post: 146806, member: 13851"] [B]Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging: A Closer Look at Laboratory Findings [/B] [B][COLOR=rgb(184, 49, 47)]Fereshteh Farajdokht, Mehdi Farhoudi, Alireza Majdi, Masumeh Zamanlu, Saeed Sadigh-Eteghad, Shabnam Vahedi, Javad Mahmoudi*[/COLOR][/B] [B][COLOR=rgb(184, 49, 47)]Abstract[/COLOR][/B] Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebral ischemia remains unclear. [COLOR=rgb(184, 49, 47)][B]Here we reviewed current understanding of testosterone (TES) neuroprotective activity against ischemic stroke and mechanisms underlying these effects in aging.[/B][/COLOR] [COLOR=rgb(41, 105, 176)][B]TES may exert a neuroprotective effect in aging through pathways including inhibition of oxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain and modulation of apoptotic cell death.[/B][/COLOR] Given this, a better understanding of the neuroprotective roles of TES may propose an effective therapeutic strategy to improve the quality of life and decrease androgen-related cerebrovascular problems in the aging men [B]Conclusion[/B] Based on above, [COLOR=rgb(184, 49, 47)][B]TES neuroprotection against stroke in aging appears to be mediated by several mechanisms[/B][/COLOR][B] [/B]including [COLOR=rgb(44, 130, 201)][B]inhibition of production of oxidant molecules, enhancing the enzymatic antioxidant capacity of the brain, activation of PI3K/AKT pathway and enhancing cell survival, inhibition of pro-apoptotic protein through AR dependent MAPK/ERK pathway, as well as improvement of brain neuronal and BBB integrities.[/B][/COLOR] [B]These mechanisms may propose future therapeutic strategies to improve the quality of life and decrease androgen-related health problems in the aging population. [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone May Hold Therapeutic Promise for the Treatment of Ischemic Stroke in Aging
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