Testosterone-Lowering Therapy for Prostate Cancer May Increase Alzheimer's Risk

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Nelson Vergel

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Beyond Testosterone Book by Nelson Vergel
Men taking androgen deprivation therapy (ADT) for prostate cancer were almost twice as likely to be diagnosed with Alzheimer’s disease in the years that followed than those who didn’t undergo the therapy, an analysis of medical records from two large hospital systems by Penn Medicine and Stanford University researchers has shown. Men with the longest durations of ADT were even more likely to be diagnosed with Alzheimer’s disease.

The findings, published in the December 7issue of the Journal of Clinical Oncology, do not prove that ADT increases the risk of Alzheimer’s disease. But the authors say they clearly point to that possibility, and are consistent with other evidence that low levels of testosterone may weaken the aging brain’s resistance to Alzheimer’s.

http://www.uphs.upenn.edu/news/News_Releases/2015/12/nead/
 
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