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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Testosterone Increased Libido in Men with Sleep Apnea
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<blockquote data-quote="Nelson Vergel" data-source="post: 28329" data-attributes="member: 3"><p><strong>Increased sexual desire with exogenous testosterone administration in men with obstructive sleep apnea: a randomized placebo-controlled study</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong><em>Melehan, K. L., Hoyos, C. M., Yee, B. J., Wong, K. K., Buchanan, P. R., Grunstein, R. R. and Liu, P. Y. (2015), Increased sexual desire with exogenous testosterone administration in men with obstructive sleep apnea: a randomized placebo-controlled study. Andrology.</em></p><p><em></em></p><p><em></em>[ATTACH]1686[/ATTACH]<strong></strong></p><p><strong></strong></p><p><strong>Summary</strong></p><p></p><p></p><p>Testosterone (T) deficiency, sexual dysfunction, obesity and obstructive sleep apnea (OSA) are common and often coexist. T prescriptions have increased worldwide during the last decade, including to those with undiagnosed or untreated OSA. The effect of T administration on sexual function, neurocognitive performance and quality of life in these men is poorly defined. The aim of this study was to examine the impact of T administration on sexual function, quality of life and neurocognitive performance in obese men with OSA. We also secondarily examined whether baseline T might modify the effects of T treatment by dichotomizing on baseline T levels pre-specified at 8, 11 and 13 nmol/L. This was a randomized placebo-controlled study in which 67 obese men with OSA (mean age 49 ± 1.3 years) were randomized to receive intramuscular injections of either 1000 mg T undecanoate or placebo at baseline, week 6 and week 12. All participants were concurrently enrolled in a weight loss program. General and sleep-related quality of life, neurocognitive performance and subjective sexual function were assessed before and 6, 12 and 18 weeks after therapy. T compared to placebo increased sexual desire (<em>p </em>=0.004) in all men, irrespective of baseline T levels. There were no differences in erectile function, frequency of sexual attempts, orgasmic ability, general or sleep-related quality of life or neurocognitive function (all <em>p</em> = NS). In those with baseline T levels below 8 nmol/L, T increased vitality (<em>p </em>=0.004), and reduced reports of feeling down (<em>p </em>=0.002) and nervousness (<em>p </em>=0.03). <strong>Our findings show that 18 weeks of T therapy increased sexual desire in obese men with OSA independently of baseline T levels whereas improvements in quality of life were evident only in those with T levels below 8 nmol/L. These small improvements would need to be balanced against potentially more serious adverse effects of T therapy on breathing.</strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 28329, member: 3"] [B]Increased sexual desire with exogenous testosterone administration in men with obstructive sleep apnea: a randomized placebo-controlled study [/B][I]Melehan, K. L., Hoyos, C. M., Yee, B. J., Wong, K. K., Buchanan, P. R., Grunstein, R. R. and Liu, P. Y. (2015), Increased sexual desire with exogenous testosterone administration in men with obstructive sleep apnea: a randomized placebo-controlled study. Andrology. [/I][ATTACH=CONFIG]1686[/ATTACH][B] Summary[/B] Testosterone (T) deficiency, sexual dysfunction, obesity and obstructive sleep apnea (OSA) are common and often coexist. T prescriptions have increased worldwide during the last decade, including to those with undiagnosed or untreated OSA. The effect of T administration on sexual function, neurocognitive performance and quality of life in these men is poorly defined. The aim of this study was to examine the impact of T administration on sexual function, quality of life and neurocognitive performance in obese men with OSA. We also secondarily examined whether baseline T might modify the effects of T treatment by dichotomizing on baseline T levels pre-specified at 8, 11 and 13 nmol/L. This was a randomized placebo-controlled study in which 67 obese men with OSA (mean age 49 ± 1.3 years) were randomized to receive intramuscular injections of either 1000 mg T undecanoate or placebo at baseline, week 6 and week 12. All participants were concurrently enrolled in a weight loss program. General and sleep-related quality of life, neurocognitive performance and subjective sexual function were assessed before and 6, 12 and 18 weeks after therapy. T compared to placebo increased sexual desire ([I]p [/I]=0.004) in all men, irrespective of baseline T levels. There were no differences in erectile function, frequency of sexual attempts, orgasmic ability, general or sleep-related quality of life or neurocognitive function (all [I]p[/I] = NS). In those with baseline T levels below 8 nmol/L, T increased vitality ([I]p [/I]=0.004), and reduced reports of feeling down ([I]p [/I]=0.002) and nervousness ([I]p [/I]=0.03). [B]Our findings show that 18 weeks of T therapy increased sexual desire in obese men with OSA independently of baseline T levels whereas improvements in quality of life were evident only in those with T levels below 8 nmol/L. These small improvements would need to be balanced against potentially more serious adverse effects of T therapy on breathing.[/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Testosterone Increased Libido in Men with Sleep Apnea
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