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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone in Atrevis hydrogel base = almost double test levels!
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<blockquote data-quote="madman" data-source="post: 211689" data-attributes="member: 13851"><p>Same concentration different volume.</p><p></p><p></p><p><em>After two screening visits, participants attended five study visits over 11 days. They were administered two intramuscular injections of nandrolone decanoate (50 mg in 1 mL Arachis oil vehicle) comprising 200 mg three days prior to and 100 mg four days after the first testosterone dose to suppress endogenous testosterone secretion throughout the study. The nandrolone dosage was selected as known to transiently suppress endogenous testosterone for the study period without adverse effects (Minto et al., 1997; Handelsman et al., 2009, 2014; Singh et al., 2014). Each eligible, consenting participant was administered three single doses of testosterone cream in a random sequence on different study days with at least 2 days wash-out period between studies. </em><strong><em>The testosterone doses were 50 mg (1 mL cream), 25 mg (0.5 mL cream), and 12.5 mg (0.25 mL cream) each drawn from the same tube for each participant with the volume (dose) of testosterone cream measured using 1 mL insulin syringe and verified by a separate investigator.</em></strong><em> A venous cannula was inserted to obtain three pre-dose baseline blood samples at 15, 5 min and immediately prior to application of the testosterone cream which was applied at 08:00 to the scrotum by the participant using a gloved hand. Blood sampling was then further undertaken at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, and 16 h post-cream application. Serum was stored frozen (-20 °C) until assay in a single batch. In addition, venous and finger-prick blood samples were spotted onto filter paper at 0, 4, 8, 12, 16, and 24 h and stored at room temperature in sealed plastic bags. T</em></p></blockquote><p></p>
[QUOTE="madman, post: 211689, member: 13851"] Same concentration different volume. [I]After two screening visits, participants attended five study visits over 11 days. They were administered two intramuscular injections of nandrolone decanoate (50 mg in 1 mL Arachis oil vehicle) comprising 200 mg three days prior to and 100 mg four days after the first testosterone dose to suppress endogenous testosterone secretion throughout the study. The nandrolone dosage was selected as known to transiently suppress endogenous testosterone for the study period without adverse effects (Minto et al., 1997; Handelsman et al., 2009, 2014; Singh et al., 2014). Each eligible, consenting participant was administered three single doses of testosterone cream in a random sequence on different study days with at least 2 days wash-out period between studies. [/I][B][I]The testosterone doses were 50 mg (1 mL cream), 25 mg (0.5 mL cream), and 12.5 mg (0.25 mL cream) each drawn from the same tube for each participant with the volume (dose) of testosterone cream measured using 1 mL insulin syringe and verified by a separate investigator.[/I][/B][I] A venous cannula was inserted to obtain three pre-dose baseline blood samples at 15, 5 min and immediately prior to application of the testosterone cream which was applied at 08:00 to the scrotum by the participant using a gloved hand. Blood sampling was then further undertaken at 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 14, and 16 h post-cream application. Serum was stored frozen (-20 °C) until assay in a single batch. In addition, venous and finger-prick blood samples were spotted onto filter paper at 0, 4, 8, 12, 16, and 24 h and stored at room temperature in sealed plastic bags. T[/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone in Atrevis hydrogel base = almost double test levels!
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