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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone gel application sites for maximum DHT
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<blockquote data-quote="Cataceous" data-source="post: 207763" data-attributes="member: 38109"><p>It looks as though you've basically answered your own question, or at least tracked down much of what's known. Just as peripheral information I'll add that emphasis on the total skin surface area has a reasonable basis. The 5α-reductase enzymes can become locally saturated. Thus you might get more DHT if you spread a low-concentration transdermal product over a large area than if you spread a high-concentration product over a small area—even when total testosterone delivered is the same.</p><p></p><p>Regarding application to the armpits, I was reminded of the Axiron product. In a study its effect on DHT is characterized this way: "DHT concentration increased in parallel with testosterone concentration during AXIRON treatment. The mean steady-state DHT/T ratio remained within normal limits and ranged from 0.17 to 0.26 across all doses on Days 15, 60, and 120."[<a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b40e56a-51bb-4357-8861-325bb1195049" target="_blank">R</a>] What catches my attention is that DHT/T ratios of 17-26% are a good bit higher than the figure of 10% that's typically cited. As a further aside, guys would sometimes shave their armpit hair in order to use Axiron more efficiently.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 207763, member: 38109"] It looks as though you've basically answered your own question, or at least tracked down much of what's known. Just as peripheral information I'll add that emphasis on the total skin surface area has a reasonable basis. The 5α-reductase enzymes can become locally saturated. Thus you might get more DHT if you spread a low-concentration transdermal product over a large area than if you spread a high-concentration product over a small area—even when total testosterone delivered is the same. Regarding application to the armpits, I was reminded of the Axiron product. In a study its effect on DHT is characterized this way: "DHT concentration increased in parallel with testosterone concentration during AXIRON treatment. The mean steady-state DHT/T ratio remained within normal limits and ranged from 0.17 to 0.26 across all doses on Days 15, 60, and 120."[[URL='https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3b40e56a-51bb-4357-8861-325bb1195049']R[/URL]] What catches my attention is that DHT/T ratios of 17-26% are a good bit higher than the figure of 10% that's typically cited. As a further aside, guys would sometimes shave their armpit hair in order to use Axiron more efficiently. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone gel application sites for maximum DHT
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