ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone for prevention and reversal of diabetes in men with low T
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 201198" data-attributes="member: 13851"><p><strong>Abstract</strong></p><p><strong></strong></p><p><strong><em>Men with obesity and/or type 2 diabetes (T2D) have a high prevalence of testosterone deficiency (TD). Similarly, men with TD has an increased risk of developing obesity and/or T2D, and further body fat accumulation and deterioration of glycemic control create a vicious cycle.</em></strong> <strong><em><u>The landmark testosterone for diabetes mellitus trial, the largest randomized controlled trial of testosterone therapy (TTh) to date, confirm the beneficial effects of TTh on fat loss and gain in muscle mass, and that TTh for 2 years significantly reduces the risk of incident T2D, and may also reverse T2D</u>. </em></strong><em><strong><u>The testosterone for diabetes mellitus trial suggests that TTh reduces the risk of T2D and results in greater improvement in sexual function and wellbeing, beyond lifestyle intervention alone</u>.</strong></em></p><p></p><p></p><p></p><p></p><p></p><p><strong>Introduction</strong></p><p></p><p>Type 2 diabetes (T2D) is one of the fastest-growing chronic diseases worldwide [1], in large part driven by (abdominal) obesity. <strong><em>Obesity is a strong risk factor for testosterone deficiency (TD), which further increases fat accumulation, insulin resistance (IR), and deterioration of glycemic control creating a vicious circle. </em></strong>Due to the common co-occurrence of obesity and T2D, the term ‘diabesity’ was proposed to describe this condition [2].</p><p></p><p>Weight loss by lifestyle intervention is a cornerstone treatment for obesity and/or T2D. However, a profound weight loss of about 10% - and maintenance of reduced body weight - is required to prevent diabetes [3,4]. <em><strong>The problem is that long-term weight loss maintenance is poor, with subjects regaining half of the lost weight after 1 year and nearly three quarter during the first three years [5-7]. Less than 3% of subjects maintain their weight loss at all annual visits for 4-5 years after completion of a weight-loss program [5-7]. Hence, lifestyle intervention alone is not sufficient to treat or prevent obesity/T2D, as demonstrated by the ongoing and increasing prevalence of these dysmetabolic conditions.</strong></em></p><p></p><p></p><p></p><p></p><p><strong>Low testosterone and IR</strong></p><p></p><p><em><strong>Men with low testosterone have increased IR [8-11], which is one of the root causes of T2D [12-17].</strong></em> The significant graded inverse association between testosterone and IR is independent of age [18] and low testosterone is associated with IR even in relatively young non-obese men [8,9,11]. <em><strong>A positive correlation has been shown between serum testosterone levels in men and insulin sensitivity, across the full spectrum of glucose tolerance regardless of age [19] Box 1.</strong></em></p><p></p><p></p><p></p><p></p><p><strong>*Randomized trials of TTh in men with T2D</strong></p><p><strong></strong></p><p><strong>*Real-world evidence studies of TTh for prevention of T2D</strong></p><p><strong></strong></p><p><strong>*Testosterone for diabetes mellitus trial – TTh for prevention T2D in men with low-normal T</strong></p><p><strong></strong></p><p><strong>*HbA1c may not be an accurate marker of glycemic control in men with low testosterone</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Discussion</strong></p><p><strong></strong></p><p><strong><em>The T4DM trial, which is the first large-scale RCT examining the efficacy and safety of TTh for the prevention of T2D in men with low testosterone levels, provides high-level evidence that TTh increases the benefits of lifestyle intervention for prevention of T2D, as well as reversal of T2D [45].</em></strong> <strong><em><u>Hence, the T4DM trial confirms findings from previous RWE studies in men with TD, which showed that treatment with testosterone undecanoate injections for 8-11 years completely prevented progression of prediabetes to T2D</u> [41] <u>and resulted in T2D remission in 34.3% of men</u> [42].</em></strong></p><p></p><p></p><p></p><p></p><p><em><strong>*The T4DM trial provides high-level evidence that TTh, as an adjunct to a lifestyle program, significantly reduces incidence of T2D in men with low testosterone and may also, reverse T2D in newly diagnosed patients. This may inform clinical decisions about the use of TTh as a pharmacotherapy for T2D prevention and healthcare cost-savings.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 201198, member: 13851"] [B]Abstract [I]Men with obesity and/or type 2 diabetes (T2D) have a high prevalence of testosterone deficiency (TD). Similarly, men with TD has an increased risk of developing obesity and/or T2D, and further body fat accumulation and deterioration of glycemic control create a vicious cycle.[/I][/B] [B][I][U]The landmark testosterone for diabetes mellitus trial, the largest randomized controlled trial of testosterone therapy (TTh) to date, confirm the beneficial effects of TTh on fat loss and gain in muscle mass, and that TTh for 2 years significantly reduces the risk of incident T2D, and may also reverse T2D[/U]. [/I][/B][I][B][U]The testosterone for diabetes mellitus trial suggests that TTh reduces the risk of T2D and results in greater improvement in sexual function and wellbeing, beyond lifestyle intervention alone[/U].[/B][/I] [B]Introduction[/B] Type 2 diabetes (T2D) is one of the fastest-growing chronic diseases worldwide [1], in large part driven by (abdominal) obesity. [B][I]Obesity is a strong risk factor for testosterone deficiency (TD), which further increases fat accumulation, insulin resistance (IR), and deterioration of glycemic control creating a vicious circle. [/I][/B]Due to the common co-occurrence of obesity and T2D, the term ‘diabesity’ was proposed to describe this condition [2]. Weight loss by lifestyle intervention is a cornerstone treatment for obesity and/or T2D. However, a profound weight loss of about 10% - and maintenance of reduced body weight - is required to prevent diabetes [3,4]. [I][B]The problem is that long-term weight loss maintenance is poor, with subjects regaining half of the lost weight after 1 year and nearly three quarter during the first three years [5-7]. Less than 3% of subjects maintain their weight loss at all annual visits for 4-5 years after completion of a weight-loss program [5-7]. Hence, lifestyle intervention alone is not sufficient to treat or prevent obesity/T2D, as demonstrated by the ongoing and increasing prevalence of these dysmetabolic conditions.[/B][/I] [B]Low testosterone and IR[/B] [I][B]Men with low testosterone have increased IR [8-11], which is one of the root causes of T2D [12-17].[/B][/I] The significant graded inverse association between testosterone and IR is independent of age [18] and low testosterone is associated with IR even in relatively young non-obese men [8,9,11]. [I][B]A positive correlation has been shown between serum testosterone levels in men and insulin sensitivity, across the full spectrum of glucose tolerance regardless of age [19] Box 1.[/B][/I] [B]*Randomized trials of TTh in men with T2D *Real-world evidence studies of TTh for prevention of T2D *Testosterone for diabetes mellitus trial – TTh for prevention T2D in men with low-normal T *HbA1c may not be an accurate marker of glycemic control in men with low testosterone Discussion [I]The T4DM trial, which is the first large-scale RCT examining the efficacy and safety of TTh for the prevention of T2D in men with low testosterone levels, provides high-level evidence that TTh increases the benefits of lifestyle intervention for prevention of T2D, as well as reversal of T2D [45].[/I][/B] [B][I][U]Hence, the T4DM trial confirms findings from previous RWE studies in men with TD, which showed that treatment with testosterone undecanoate injections for 8-11 years completely prevented progression of prediabetes to T2D[/U] [41] [U]and resulted in T2D remission in 34.3% of men[/U] [42].[/I][/B] [I][B]*The T4DM trial provides high-level evidence that TTh, as an adjunct to a lifestyle program, significantly reduces incidence of T2D in men with low testosterone and may also, reverse T2D in newly diagnosed patients. This may inform clinical decisions about the use of TTh as a pharmacotherapy for T2D prevention and healthcare cost-savings.[/B][/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone for prevention and reversal of diabetes in men with low T
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top