ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone/Estradiol Ratio
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Cataceous" data-source="post: 198436" data-attributes="member: 38109"><p><em>(a) 17‐α‐estradiol (17aE2) is a relatively “non‐feminizing” estrogen which shows reduced activation of classical estrogen receptors compared with 17‐β‐estradiol (Anstead et al., <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328#acel13328-bib-0001" target="_blank">1997</a>). Harrison et al. (<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328#acel13328-bib-0012" target="_blank">2014</a>) reported that in UM‐HET3 mice fed 4.8 mg 17aE2/kg (4.8 ppm) diet from 10 months of age, median male lifespans increased 12% (p = 0.0012, pooled across the three sites), while 17aE2 did not alter female lifespan. Strong et al. (<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328#acel13328-bib-0031" target="_blank">2016</a>) showed that using a threefold higher dose (14.4 ppm) from 10 months of age, pooled median male lifespans increased 19% (p < 0.001); the 90% lifespan increased 12%, but females still did not benefit. Thus, only males were tested in the present study. To determine whether 17aE2 treatment is effective when initiated in older mice, males were treated beginning at 16 or 20 months of age, choosing middle age, and early old age before many natural deaths.</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 198436, member: 38109"] [I](a) 17‐α‐estradiol (17aE2) is a relatively “non‐feminizing” estrogen which shows reduced activation of classical estrogen receptors compared with 17‐β‐estradiol (Anstead et al., [URL='https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328#acel13328-bib-0001']1997[/URL]). Harrison et al. ([URL='https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328#acel13328-bib-0012']2014[/URL]) reported that in UM‐HET3 mice fed 4.8 mg 17aE2/kg (4.8 ppm) diet from 10 months of age, median male lifespans increased 12% (p = 0.0012, pooled across the three sites), while 17aE2 did not alter female lifespan. Strong et al. ([URL='https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13328#acel13328-bib-0031']2016[/URL]) showed that using a threefold higher dose (14.4 ppm) from 10 months of age, pooled median male lifespans increased 19% (p < 0.001); the 90% lifespan increased 12%, but females still did not benefit. Thus, only males were tested in the present study. To determine whether 17aE2 treatment is effective when initiated in older mice, males were treated beginning at 16 or 20 months of age, choosing middle age, and early old age before many natural deaths.[/I] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone/Estradiol Ratio
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top