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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone/Estradiol Ratio
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<blockquote data-quote="Cataceous" data-source="post: 198086" data-attributes="member: 38109"><p>One way to consider the ratio is as the fraction of testosterone that is converted to estradiol. Typically this ranges from around 0.3 to 0.6%. The calculation is performed by dividing estradiol in pg/mL by 10 to convert to ng/dL, and then dividing this result by total testosterone in ng/dL. It's also common to consider a T:E2 ratio, which directly divides total testosterone in ng/dL by estradiol in pg/mL. The normal range then becomes about 16-30.</p><p></p><p>There is evidence that elevated estradiol in the presence of low testosterone is harmful. However, I don't view this as a green light to sky-high estradiol when accompanied by similarly high testosterone. It's still quite possible that high absolute levels of estradiol are problematic in some ways. The obvious solution is to maintain testosterone at a level that yields normal estradiol—after all, our bodies naturally regulate testosterone mainly by the level of (free) estradiol. The exception is when aromatization is excessive, i.e. causing an E2:T ratio above a normal range and seeming to cause symptoms. Ideally the aromatization rate would be decreased naturally, such as through weight loss. But this isn't always possible.</p><p></p><p>Looking at the specific numbers you gave, estradiol is 0.38% of testosterone, and the T:E2 ratio is 26. This implies aromatization is a little below average. It would be unremarkable if it occurred naturally, but as you note, there is increasing concern about the long-term consequences of skewing the ratio via aromatase inhibition. As I said in the other thread, you have room for a significant testosterone dose reduction, so in the long run you may be able to manage estradiol appropriately without using an AI. Keep in mind that a temporary excess of aromatization is possible after non-suicidal AIs—such as anastrozole—are discontinued.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 198086, member: 38109"] One way to consider the ratio is as the fraction of testosterone that is converted to estradiol. Typically this ranges from around 0.3 to 0.6%. The calculation is performed by dividing estradiol in pg/mL by 10 to convert to ng/dL, and then dividing this result by total testosterone in ng/dL. It's also common to consider a T:E2 ratio, which directly divides total testosterone in ng/dL by estradiol in pg/mL. The normal range then becomes about 16-30. There is evidence that elevated estradiol in the presence of low testosterone is harmful. However, I don't view this as a green light to sky-high estradiol when accompanied by similarly high testosterone. It's still quite possible that high absolute levels of estradiol are problematic in some ways. The obvious solution is to maintain testosterone at a level that yields normal estradiol—after all, our bodies naturally regulate testosterone mainly by the level of (free) estradiol. The exception is when aromatization is excessive, i.e. causing an E2:T ratio above a normal range and seeming to cause symptoms. Ideally the aromatization rate would be decreased naturally, such as through weight loss. But this isn't always possible. Looking at the specific numbers you gave, estradiol is 0.38% of testosterone, and the T:E2 ratio is 26. This implies aromatization is a little below average. It would be unremarkable if it occurred naturally, but as you note, there is increasing concern about the long-term consequences of skewing the ratio via aromatase inhibition. As I said in the other thread, you have room for a significant testosterone dose reduction, so in the long run you may be able to manage estradiol appropriately without using an AI. Keep in mind that a temporary excess of aromatization is possible after non-suicidal AIs—such as anastrozole—are discontinued. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone/Estradiol Ratio
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