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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Doubles Risk of Thromboembolism
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<blockquote data-quote="Jinzang" data-source="post: 162984" data-attributes="member: 12925"><p>A new study finds an increased risk of venous thromboembolism (VTE) in the six months after starting testosterone replacement therapy compared to the six months before the therapy was initiated. The <a href="https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2754091" target="_blank">abstract</a> says:</p><p></p><p>This case-crossover study analyzed data on 39 622 men from the IBM MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental Database from January 1, 2011, to December 31, 2017, with 12 months of follow-up. Men with VTE cases who were free of cancer at baseline and had 12 months of continuous enrollment before the VTE event were identified by <em>International Classification of Diseases</em> codes. Men in the case period were matched with themselves in the control period.</p><p></p><p>A total of 39 622 men (mean [SD] age, 57.4 [14.2] years) were enrolled in the study, and 3110 men (7.8%) had evidence of hypogonadism. In age-adjusted models, testosterone therapy use in all case periods was associated with a higher risk of VTE in men with (odds ratio [OR], 2.32; 95% CI, 1.97-2.74) and without (OR, 2.02; 95% CI, 1.47-2.77) hypogonadism. Among men without hypogonadism, the point estimate for testosterone therapy and VTE risk in the 3-month case period was higher for men younger than 65 years (OR, 2.99; 95% CI, 1.91-4.68) than for older men (OR, 1.68; 95% CI, 0.90-3.14), although this interaction was not statistically significant (<em>P</em> = .14).</p></blockquote><p></p>
[QUOTE="Jinzang, post: 162984, member: 12925"] A new study finds an increased risk of venous thromboembolism (VTE) in the six months after starting testosterone replacement therapy compared to the six months before the therapy was initiated. The [URL='https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2754091']abstract[/URL] says: This case-crossover study analyzed data on 39 622 men from the IBM MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental Database from January 1, 2011, to December 31, 2017, with 12 months of follow-up. Men with VTE cases who were free of cancer at baseline and had 12 months of continuous enrollment before the VTE event were identified by [I]International Classification of Diseases[/I] codes. Men in the case period were matched with themselves in the control period. A total of 39 622 men (mean [SD] age, 57.4 [14.2] years) were enrolled in the study, and 3110 men (7.8%) had evidence of hypogonadism. In age-adjusted models, testosterone therapy use in all case periods was associated with a higher risk of VTE in men with (odds ratio [OR], 2.32; 95% CI, 1.97-2.74) and without (OR, 2.02; 95% CI, 1.47-2.77) hypogonadism. Among men without hypogonadism, the point estimate for testosterone therapy and VTE risk in the 3-month case period was higher for men younger than 65 years (OR, 2.99; 95% CI, 1.91-4.68) than for older men (OR, 1.68; 95% CI, 0.90-3.14), although this interaction was not statistically significant ([I]P[/I] = .14). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Doubles Risk of Thromboembolism
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