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This is what Dr Rotman, an urologist from New York city said:


"The best marker we have for prostate cancer is still the PSA test. The faster the rise in psa and the higher the score the more likely one is to have advanced prostate cancer. We know by chemically castrating a patient (Lupron etc) one is halting the growth of prostate cancer and lowering the psa. Now when someone has castrate resistant prostate cancer, meaning the testosterone has no effect on cancer growth, testosterone does not play as important part a role anymore and we use alternative treatments such as chemotherapy and other androgen receptor blockers. 


In regards to age and psa, as one gets older the prostate tends to grow as well and therefore psa rises as well. We have psa  ranges for different ages so as to limit the patients who undergo unnecessary biopsies. So while a psa up to 2.5 is normal for 50 year old patient , a psa up to 4 would be normal for a 70 year old. "


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