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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone dimers
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<blockquote data-quote="granger" data-source="post: 260872" data-attributes="member: 45577"><p>in this one they acquired the separate dimmers just to study how they differ, but are part of normal/natural test from what I gather. I missed the part it says it obtained separate dimmers from sigma and were talking about generally how endogenous test reacts differently to blood proteins in vivo..</p><p></p><p>"HSA forms more stable complexes than BSA. The <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/binding-affinity" target="_blank">binding affinity</a> of steroid–protein adducts is testosterone > dimer-aromatic > dimer-aliphatic"</p><p> "Due to a major biological importance of steroid–protein interaction, it was of interest to examine the associations of testosterone and two of its dimers with serum albumins"</p><p>"his study was undertaken to verify the potential transportation of testosterone and its dimers by serum proteins. The significance of this study resides in the likely development of testosterone delivery system for the treatment of androgen deficiency in men"</p><p></p><p>found the old article about dimmers and esters! they use aromatic and aliphatic to refer to the dimmers and dont call them dimmers. interesting it makes note of certain esters being more aliphatic, from what I gather.</p><p> "lower aliphatic esters are most effective.... the effect are more pronounced but intensity decrease rapidly"... im just reading it now but im sure this will help answer more questions esp if look into its citations. unfortunate need a subscription in order to read full article, and of course pretty intense chemistry talk.</p><p>[URL unfurl="true"]https://pubs.acs.org/doi/pdf/10.1021/ja01178a030[/URL]</p><p></p><p>at any rate, I think for a definite answer would need to speak with someone far more knowledgable. and agree prob more academic than practical, and wish we had a dr here who could break this down. but MAY offer a little insight in practical terms for some people, I just find it interesting</p><p></p><p>[USER=39921]@bixt[/USER] yes some meds are 1 singular compound so yes differing delivery methods would of course make a noticeable change and unlikely the 5% dosage difference from a different brand would be noticeable however differing XR methods would. I was talking about drugs that are not one singular compound like HCG or clomid... and hence more than possible notable difference. I dont know clomid for example has defined strict ratios of enclomophene etc. HCG of course uses IU vs mg as measure effectiveness vs mg dosage per say, thats to say one hcg mg may equal higher iu than 1mg of a different hcg brand thats recombinant for example. again, I think my point was that MANY drugs are not 1 singular thing. even vitamins b12 isn't just 1 thing neither is vitamin D. IIRC even differing vitamin C isomers work differently by the body..</p></blockquote><p></p>
[QUOTE="granger, post: 260872, member: 45577"] in this one they acquired the separate dimmers just to study how they differ, but are part of normal/natural test from what I gather. I missed the part it says it obtained separate dimmers from sigma and were talking about generally how endogenous test reacts differently to blood proteins in vivo.. "HSA forms more stable complexes than BSA. The [URL='https://www.sciencedirect.com/topics/medicine-and-dentistry/binding-affinity']binding affinity[/URL] of steroid–protein adducts is testosterone > dimer-aromatic > dimer-aliphatic" "Due to a major biological importance of steroid–protein interaction, it was of interest to examine the associations of testosterone and two of its dimers with serum albumins" "his study was undertaken to verify the potential transportation of testosterone and its dimers by serum proteins. The significance of this study resides in the likely development of testosterone delivery system for the treatment of androgen deficiency in men" found the old article about dimmers and esters! they use aromatic and aliphatic to refer to the dimmers and dont call them dimmers. interesting it makes note of certain esters being more aliphatic, from what I gather. "lower aliphatic esters are most effective.... the effect are more pronounced but intensity decrease rapidly"... im just reading it now but im sure this will help answer more questions esp if look into its citations. unfortunate need a subscription in order to read full article, and of course pretty intense chemistry talk. [URL unfurl="true"]https://pubs.acs.org/doi/pdf/10.1021/ja01178a030[/URL] at any rate, I think for a definite answer would need to speak with someone far more knowledgable. and agree prob more academic than practical, and wish we had a dr here who could break this down. but MAY offer a little insight in practical terms for some people, I just find it interesting [USER=39921]@bixt[/USER] yes some meds are 1 singular compound so yes differing delivery methods would of course make a noticeable change and unlikely the 5% dosage difference from a different brand would be noticeable however differing XR methods would. I was talking about drugs that are not one singular compound like HCG or clomid... and hence more than possible notable difference. I dont know clomid for example has defined strict ratios of enclomophene etc. HCG of course uses IU vs mg as measure effectiveness vs mg dosage per say, thats to say one hcg mg may equal higher iu than 1mg of a different hcg brand thats recombinant for example. again, I think my point was that MANY drugs are not 1 singular thing. even vitamins b12 isn't just 1 thing neither is vitamin D. IIRC even differing vitamin C isomers work differently by the body.. [/QUOTE]
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