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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone dimers
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<blockquote data-quote="granger" data-source="post: 260689" data-attributes="member: 45577"><p>yes its in plenty of literature, including one I posted. reading it all is one story, than comprehension is yet another lol...</p><p></p><p>dimmers are simply same hormone in this case folded / reacted / polymerized with each other not reacted in an acid base type of way. if that makes sense.. aliphatic testosterone being 1 dimmer type, aromatic another form it would seem.</p><p></p><p>it would appear have differing types of dimmer some man made and some natural. one old paper talked about "new"(at the time) esters and dimmer trying to Dig that up but not seeing it atm..</p><p></p><p>this one is talking about in vivo/endogenous ie natural. and varying forms, varying affinity to proteins one would assume would have varying effects as we know about "bound" test and free test in trt. I think they wanted to encapsulate test with proteins to make it more or less effective for varying reasons... <a href="https://www.sciencedirect.com/science/article/abs/pii/S1011134415002936" target="_blank">Transporting testosterone and its dimers by serum proteins</a></p><p></p><p>again, I am not an expert and I am just as curious as you about test dimmers and how different ratios may cause differing effects.. as paper describes different dimmers reacting with DNA and RNA differently presumably having slightly different effects along with how they bind to blood albumin etc. perhaps insignificant, and more for cancer research and drug development. is there a endocrinologist in the house?? lol</p><p></p><p>rather academic pursuit but I find it interesting, and perhaps in the future may help us understand oddities and quarks of different test product. or may have very little to do with anything, but we can learn together...</p></blockquote><p></p>
[QUOTE="granger, post: 260689, member: 45577"] yes its in plenty of literature, including one I posted. reading it all is one story, than comprehension is yet another lol... dimmers are simply same hormone in this case folded / reacted / polymerized with each other not reacted in an acid base type of way. if that makes sense.. aliphatic testosterone being 1 dimmer type, aromatic another form it would seem. it would appear have differing types of dimmer some man made and some natural. one old paper talked about "new"(at the time) esters and dimmer trying to Dig that up but not seeing it atm.. this one is talking about in vivo/endogenous ie natural. and varying forms, varying affinity to proteins one would assume would have varying effects as we know about "bound" test and free test in trt. I think they wanted to encapsulate test with proteins to make it more or less effective for varying reasons... [URL='https://www.sciencedirect.com/science/article/abs/pii/S1011134415002936']Transporting testosterone and its dimers by serum proteins[/URL] again, I am not an expert and I am just as curious as you about test dimmers and how different ratios may cause differing effects.. as paper describes different dimmers reacting with DNA and RNA differently presumably having slightly different effects along with how they bind to blood albumin etc. perhaps insignificant, and more for cancer research and drug development. is there a endocrinologist in the house?? lol rather academic pursuit but I find it interesting, and perhaps in the future may help us understand oddities and quarks of different test product. or may have very little to do with anything, but we can learn together... [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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