ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Testosterone Cypionate vs Testosterone Undecanoate
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="testiculus" data-source="post: 253704" data-attributes="member: 17128"><p>You probably know all this, but here's my speculation as to what's happening. From Bhasin, the incidence of side effects from supraphysiologic doses of testosterone is higher in older men, than in young men.</p><p></p><h3><a href="https://pubmed.ncbi.nlm.nih.gov/15562020/" target="_blank">Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle</a></h3><p></p><p>Men who genetically are high responders to testosterone (AR sensitivity) are more likely suffer from adverse hematocrit effects from TRT. Given your competitive powerlifting history, you likely fall into this category.</p><p></p><h3><a href="https://pubmed.ncbi.nlm.nih.gov/17635942/" target="_blank">Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men</a></h3><p></p><p>Many factors affect the pharmacokinetics of various testosterone preparations. When going from test undecanoate to test cypionate it's not just the shorter ester that reduces the half life. The carrier oil affects the half life as does the size of the oil depot. I don't know what preparation you were using of TU but the commercial preparations use castor oil, which due to its high viscosity extends the half life by slowing dissolution into surrounding tissue. The infrequent dosing results in a large oil depot which also slows dissolution (less surface area to volume ratio of the depot). It is possible that your particular physiology results in very slow dissolution of the oil depot with monthly TU injections, but relatively rapid de-estrification, such that when switching to TC every 5 days, results in much faster dissolution (due to smaller oil depot and different carrier oil) along with even faster de-estrification, giving you a large supraphysiologic peak post injection that you don't experience with monthly TU. The supraphysiologic peak then drives the increase in hematocrit.</p><p></p><p>Have you tried daily dosing to achieve stable levels? For some that reduces hematocrit. Daily doesn't work for me, as it didn't reduce my hematocrit at all and creates other issues. Everyone is different. Some respond well to very stable T levels, others need variation. Good luck figuring things out.</p></blockquote><p></p>
[QUOTE="testiculus, post: 253704, member: 17128"] You probably know all this, but here's my speculation as to what's happening. From Bhasin, the incidence of side effects from supraphysiologic doses of testosterone is higher in older men, than in young men. [HEADING=2][URL='https://pubmed.ncbi.nlm.nih.gov/15562020/']Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle[/URL][/HEADING] Men who genetically are high responders to testosterone (AR sensitivity) are more likely suffer from adverse hematocrit effects from TRT. Given your competitive powerlifting history, you likely fall into this category. [HEADING=2][URL='https://pubmed.ncbi.nlm.nih.gov/17635942/']Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men[/URL][/HEADING] Many factors affect the pharmacokinetics of various testosterone preparations. When going from test undecanoate to test cypionate it's not just the shorter ester that reduces the half life. The carrier oil affects the half life as does the size of the oil depot. I don't know what preparation you were using of TU but the commercial preparations use castor oil, which due to its high viscosity extends the half life by slowing dissolution into surrounding tissue. The infrequent dosing results in a large oil depot which also slows dissolution (less surface area to volume ratio of the depot). It is possible that your particular physiology results in very slow dissolution of the oil depot with monthly TU injections, but relatively rapid de-estrification, such that when switching to TC every 5 days, results in much faster dissolution (due to smaller oil depot and different carrier oil) along with even faster de-estrification, giving you a large supraphysiologic peak post injection that you don't experience with monthly TU. The supraphysiologic peak then drives the increase in hematocrit. Have you tried daily dosing to achieve stable levels? For some that reduces hematocrit. Daily doesn't work for me, as it didn't reduce my hematocrit at all and creates other issues. Everyone is different. Some respond well to very stable T levels, others need variation. Good luck figuring things out. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Testosterone Cypionate vs Testosterone Undecanoate
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top