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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Cream- Scrotum VS other areas
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<blockquote data-quote="Fortunate" data-source="post: 243756" data-attributes="member: 42264"><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599554/" target="_blank">This</a> is not a great study. Retrospective with small numbers. But, done at a reputable place. They compare injections vs. gel vs. pellets and their affects on a number of parameters. I didn't read it closely enough to see if the doses were comparable. In any case, they conclude that injections and gels raise E2 while pellets don't. Not earth shattering. They then make the to-be-expected observations that such changes are simply tied to testosterone changes. Again, not earth shattering. </p><p></p><p>That said, the data may give me some hints as to why some (including me) have struggled on creams/gels. Large swings in testosterone leads to large swings in downstream metabolites. I suspect that my T levels spike, and thus my E2 spikes. My guess is that the E2 spikes make me feel the negative side effects I associate with creams/gels.</p><p></p><p>There are data that suggests woman who get migraines are most prone with dropping estrogen levels around their menstruation. My gut tells me that any rapid change in this hormone (up or down) can make some feel bad.</p><p></p><p>As of now, I am still trialing hydrogel, 75mg once a day. The dose is comparable to any of the commercially available dosing recommendations. </p><p></p><p>Early observations: More energy and mental clarity; low level anxiety that appears late morning and peaks its head up here and there throughout the day; return of morning wood (which I don't really care about, but did notice it); maybe more prone to getting a headache than usual.</p></blockquote><p></p>
[QUOTE="Fortunate, post: 243756, member: 42264"] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599554/']This[/URL] is not a great study. Retrospective with small numbers. But, done at a reputable place. They compare injections vs. gel vs. pellets and their affects on a number of parameters. I didn't read it closely enough to see if the doses were comparable. In any case, they conclude that injections and gels raise E2 while pellets don't. Not earth shattering. They then make the to-be-expected observations that such changes are simply tied to testosterone changes. Again, not earth shattering. That said, the data may give me some hints as to why some (including me) have struggled on creams/gels. Large swings in testosterone leads to large swings in downstream metabolites. I suspect that my T levels spike, and thus my E2 spikes. My guess is that the E2 spikes make me feel the negative side effects I associate with creams/gels. There are data that suggests woman who get migraines are most prone with dropping estrogen levels around their menstruation. My gut tells me that any rapid change in this hormone (up or down) can make some feel bad. As of now, I am still trialing hydrogel, 75mg once a day. The dose is comparable to any of the commercially available dosing recommendations. Early observations: More energy and mental clarity; low level anxiety that appears late morning and peaks its head up here and there throughout the day; return of morning wood (which I don't really care about, but did notice it); maybe more prone to getting a headache than usual. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Testosterone Cream- Scrotum VS other areas
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