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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Assays
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<blockquote data-quote="madman" data-source="post: 253498" data-attributes="member: 13851"><p>This is critical!</p><p></p><p>*<em><strong>Equilibrium dialysis, <u>if performed under standardized conditions</u>, represents the gold standard for the detection of free testosterone</strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The measurement of free testosterone can be accomplished by equilibrium dialysis, IAs, and calculations that use algorithms to estimate the value based on measurements of total testosterone, SHBG, and albumin within the sample of interest.</strong></em><strong> <em><u>Equilibrium dialysis is the gold standard, which requires standardized conditions</u> and is, therefore, more technically challenging and time-consuming than the other methods.</em></strong><em><strong> <u>IAs are highly inaccurate and, although widely available and inexpensive, are not recommended</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong> IAs, which are widely available at large and small laboratories, are relatively inexpensive and easily performed over short operating times. <u>Measurements of free testosterone, which is present at relatively low concentrations, are often inaccurate due to alterations in the levels of SHBG</u>. <u>For these reasons, the use of IAs is not recommended for the measurement of free testosterone</u></strong></em></strong></em></p><p><em><strong><em><strong></strong></em></strong></em></p><p><em><strong><em><strong>*<em><strong>Calculation of free testosterone relies on the measurement of total testosterone, SHBG, and albumin within the sample of interest. <u>Calculation of free testosterone is performed according to the law of mass action while utilizing the specific dissociation constants of the other analytes measured within the sample</u>. <u>In this method, the measurement accuracy of the concentrations of analytes determines the accuracy of the calculated free testosterone value</u>.</strong></em></strong></em></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong>The lack of common reference intervals, which <u>rely on faulty models of testosterone to SHBG ratios</u>, fosters potential misinterpretation of estimates of free testosterone</strong></em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 253498, member: 13851"] This is critical! *[I][B]Equilibrium dialysis, [U]if performed under standardized conditions[/U], represents the gold standard for the detection of free testosterone *The measurement of free testosterone can be accomplished by equilibrium dialysis, IAs, and calculations that use algorithms to estimate the value based on measurements of total testosterone, SHBG, and albumin within the sample of interest.[/B][/I][B] [I][U]Equilibrium dialysis is the gold standard, which requires standardized conditions[/U] and is, therefore, more technically challenging and time-consuming than the other methods.[/I][/B][I][B] [U]IAs are highly inaccurate and, although widely available and inexpensive, are not recommended[/U] *[I][B] IAs, which are widely available at large and small laboratories, are relatively inexpensive and easily performed over short operating times. [U]Measurements of free testosterone, which is present at relatively low concentrations, are often inaccurate due to alterations in the levels of SHBG[/U]. [U]For these reasons, the use of IAs is not recommended for the measurement of free testosterone[/U] *[I][B]Calculation of free testosterone relies on the measurement of total testosterone, SHBG, and albumin within the sample of interest. [U]Calculation of free testosterone is performed according to the law of mass action while utilizing the specific dissociation constants of the other analytes measured within the sample[/U]. [U]In this method, the measurement accuracy of the concentrations of analytes determines the accuracy of the calculated free testosterone value[/U].[/B][/I][/B][/I] *[I][B]The lack of common reference intervals, which [U]rely on faulty models of testosterone to SHBG ratios[/U], fosters potential misinterpretation of estimates of free testosterone[/B][/I][/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Assays
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