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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Assays
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<blockquote data-quote="madman" data-source="post: 253497" data-attributes="member: 13851"><p><strong>Box 1 Clinical Care Points </strong></p><p><strong></strong></p><p><strong><em>*A diagnosis of hypogonadism should only be made in men with symptoms and signs consistent with testosterone deficiency and unequivocally low serum T concentrations on at least two early morning tests</em></strong></p><p></p><p><em><strong>*Testosterone levels in men should be assessed in the early morning in a fasting state. Low testosterone values should be repeated </strong></em></p><p></p><p><strong><em>*The use of accurate assays for the measurement of testosterone and rigorously derived reference ranges for the interpretation of testosterone levels is necessary for the diagnosis of hypogonadism</em></strong></p><p></p><p><em><strong>*Mass spectrometry is the gold standard measurement assay for total testosterone, while certain immunoassays may be an inexpensive and widely available testosterone assay suitable for eugonadal men </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Caution should be taken in the evaluation of low testosterone, including in women and children. Commercially available immunoassays may not be accurate at low levels of serum testosterone </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*Free testosterone measurement has demonstrated utility in men demonstrating borderline low levels of total testosterone. Equilibrium dialysis followed by detection with mass spectrometry or estimations via calculations should be utilized to measure free testosterone. <u>Immunoassays should not be used</u></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The CDC Hormone Standardization Program can be utilized to assess the accreditation status of laboratories within the United States </strong></em></p><p></p><p><strong><em>*For appropriate interpretation of assay results, clinical urologists need to be up to date on published reference ranges, including age-related and sex-related standard hormone ranges</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 253497, member: 13851"] [B]Box 1 Clinical Care Points [I]*A diagnosis of hypogonadism should only be made in men with symptoms and signs consistent with testosterone deficiency and unequivocally low serum T concentrations on at least two early morning tests[/I][/B] [I][B]*Testosterone levels in men should be assessed in the early morning in a fasting state. Low testosterone values should be repeated [/B][/I] [B][I]*The use of accurate assays for the measurement of testosterone and rigorously derived reference ranges for the interpretation of testosterone levels is necessary for the diagnosis of hypogonadism[/I][/B] [I][B]*Mass spectrometry is the gold standard measurement assay for total testosterone, while certain immunoassays may be an inexpensive and widely available testosterone assay suitable for eugonadal men *Caution should be taken in the evaluation of low testosterone, including in women and children. Commercially available immunoassays may not be accurate at low levels of serum testosterone *Free testosterone measurement has demonstrated utility in men demonstrating borderline low levels of total testosterone. Equilibrium dialysis followed by detection with mass spectrometry or estimations via calculations should be utilized to measure free testosterone. [U]Immunoassays should not be used[/U] *The CDC Hormone Standardization Program can be utilized to assess the accreditation status of laboratories within the United States [/B][/I] [B][I]*For appropriate interpretation of assay results, clinical urologists need to be up to date on published reference ranges, including age-related and sex-related standard hormone ranges[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone Assays
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