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Thanks for that great info! I take .5 mg once a week now and I'm at the high end of normal for estradiol at 32.2 pg/mL. I know you are correct about low estradiol lowering bone density but I'm worried if I stop anastrozole and my estradiol increases out of the normal range I run the risk of ED, depression, and increased fat.

[QUOTE="Larry B, post: 197927, member: 41127"] Thanks for that great info! I take .5 mg once a week now and I'm at the high end of normal for estradiol at 32.2 pg/mL. I know you are correct about low estradiol lowering bone density but I'm worried if I stop anastrozole and my estradiol increases out of the normal range I run the risk of ED, depression, and increased fat. [/QUOTE]