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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone and Exercise in Middle-to-Older Aged Men
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<blockquote data-quote="madman" data-source="post: 196395" data-attributes="member: 13851"><p><strong>Combined and Independent Effects on Vascular Function</strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong></strong></p><p><strong>Abstract</strong></p><p></p><p>The endothelium is integral to the maintenance of vascular health in humans, and advancing age and low testosterone levels are associated with endothelial dysfunction in men.<strong><em> We compared the impacts of testosterone and exercise training, alone and in combination, on endothelium-dependent flow-mediated dilation % and endothelium-independent glyceryl trinitrate % responses. In this 2×2 factorial 12-week randomized controlled trial, 80 men aged 50 to 70 years with waist girth ≥95 cm and low-normal serum testosterone levels (6–14 nmol/L) were randomized to transdermal AndroForte5 (testosterone 5.0% w/v, 100 mg/2 mL; testosterone), or matching placebo; and to supervised center-based exercise or no additional exercise.</em></strong> Testosterone increased serum testosterone levels (testosterone×time, <em>P</em>=0.003) to the extent that 62% of subjects in testosterone groups increased levels to >14 nmol/L, whereas placebo treatment had no impact on testosterone levels. Exercise training increased flow-mediated dilation % (exercise×time,<em>P</em>=0.033; testosterone+exercise: +0.5, placebo+exercise: +1.0 versus testosterone+no additional exercise: −0.7, placebo+no additional exercise: +0.2%), whereas testosterone did not impact flow-mediated dilation, nor was it additive to exercise (all <em>P</em>>0.05). There were no significant exercise or drug main effects on glyceryl trinitrate responses (all <em>P</em>>0.05). <strong><em>E<u>xercise training improved endothelium-dependent vasodilator function, whereas administration of testosterone at therapeutic doses did not impact flow-mediated dilation % or add to the exercise benefit</u>. <u>Vascular smooth muscle sensitivity to nitric oxide was not modified by exercise, testosterone, or their combination</u>.<u> In middle-to-older-aged men with central adiposity and low/normal testosterone levels, we observed no evidence that testosterone added to the beneficial impact of exercise on vascular function and health</u>.</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 196395, member: 13851"] [B]Combined and Independent Effects on Vascular Function Abstract[/B] The endothelium is integral to the maintenance of vascular health in humans, and advancing age and low testosterone levels are associated with endothelial dysfunction in men.[B][I] We compared the impacts of testosterone and exercise training, alone and in combination, on endothelium-dependent flow-mediated dilation % and endothelium-independent glyceryl trinitrate % responses. In this 2×2 factorial 12-week randomized controlled trial, 80 men aged 50 to 70 years with waist girth ≥95 cm and low-normal serum testosterone levels (6–14 nmol/L) were randomized to transdermal AndroForte5 (testosterone 5.0% w/v, 100 mg/2 mL; testosterone), or matching placebo; and to supervised center-based exercise or no additional exercise.[/I][/B] Testosterone increased serum testosterone levels (testosterone×time, [I]P[/I]=0.003) to the extent that 62% of subjects in testosterone groups increased levels to >14 nmol/L, whereas placebo treatment had no impact on testosterone levels. Exercise training increased flow-mediated dilation % (exercise×time,[I]P[/I]=0.033; testosterone+exercise: +0.5, placebo+exercise: +1.0 versus testosterone+no additional exercise: −0.7, placebo+no additional exercise: +0.2%), whereas testosterone did not impact flow-mediated dilation, nor was it additive to exercise (all [I]P[/I]>0.05). There were no significant exercise or drug main effects on glyceryl trinitrate responses (all [I]P[/I]>0.05). [B][I]E[U]xercise training improved endothelium-dependent vasodilator function, whereas administration of testosterone at therapeutic doses did not impact flow-mediated dilation % or add to the exercise benefit[/U]. [U]Vascular smooth muscle sensitivity to nitric oxide was not modified by exercise, testosterone, or their combination[/U].[U] In middle-to-older-aged men with central adiposity and low/normal testosterone levels, we observed no evidence that testosterone added to the beneficial impact of exercise on vascular function and health[/U].[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Testosterone and Exercise in Middle-to-Older Aged Men
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