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Testosterone & E2 Mediate HDL Particle Size
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<blockquote data-quote="Excel Male" data-source="post: 273081" data-attributes="member: 1"><p>Exogenous testosterone decreases serum levels of high-density lipoprotein cholesterol (HDL-C) in men, but whether this reflects altered HDL function is uncertain.</p><p>[ul]</p><p> [li]Healthy men (n=45, 19-55 years of age) were rendered medically castrate with the GnRH antagonist acyline for 4 weeks and administered either 1) placebo gel, 2) low-dose testosterone gel (1.62%, 1.25 g), 3) full replacement dose testosterone gel (5 g) or 4) full replacement dose testosterone gel with an aromatase inhibitor.[/li]</p><p> [li]At baseline and end-of-<strong><a href="https://www.excelmale.com/how-to-increase-testosterone-naturally-2/" target="_blank">treatment</a></strong>, serum total and ABCA1-specific CEC were quantified, and HDL particle size and concentration were measured through calibrated ion mobility analysis.[/li]</p><p> [li]As expected, a significant time-by-group interaction was observed for serum levels of HDL-C, with significant increases in HDL-C evident after both complete and partial testosterone deprivation.[/li]</p><p> [li]However, serum testosterone level was not associated with changes in CEC. In contrast, change in serum 17?-estradiol level exhibited an inverse association with ABCA1-specific efflux (?=-0.48 per 10 pg/mL change in serum 17?-estradiol, p=0.002).[/li]</p><p> [li]Change in l-HDL-P% correlated inversely with change in serum testosterone level, but positively with change in serum 17?-estradiol level (?=0.50 per 10 pg/mL change in serum 17?-estradiol, p=0.001).[/li]</p><p>[/ul]</p><p>Testosterone-mediated changes in serum HDL-C may not reflect changes in HDL CEC. Testosterone and estradiol both may contribute to the regulation of HDL particle size in men.</p><p></p><p>"Testosterone and Estradiol Mediate Discrete Effects on High-density Lipoprotein Particle Size and Sterol Efflux Capacity in Healthy Men," [style=font-style: italic;]Circulation,[/style]2017, 136 <a href="http://circ.ahajournals.org/content/136/Suppl_1/A14585" target="_blank">http://circ.ahajournals.org/content/136/Suppl_1/A14585</a></p></blockquote><p></p>
[QUOTE="Excel Male, post: 273081, member: 1"] Exogenous testosterone decreases serum levels of high-density lipoprotein cholesterol (HDL-C) in men, but whether this reflects altered HDL function is uncertain. [ul] [li]Healthy men (n=45, 19-55 years of age) were rendered medically castrate with the GnRH antagonist acyline for 4 weeks and administered either 1) placebo gel, 2) low-dose testosterone gel (1.62%, 1.25 g), 3) full replacement dose testosterone gel (5 g) or 4) full replacement dose testosterone gel with an aromatase inhibitor.[/li] [li]At baseline and end-of-[b][url=https://www.excelmale.com/how-to-increase-testosterone-naturally-2/]treatment[/url][/b], serum total and ABCA1-specific CEC were quantified, and HDL particle size and concentration were measured through calibrated ion mobility analysis.[/li] [li]As expected, a significant time-by-group interaction was observed for serum levels of HDL-C, with significant increases in HDL-C evident after both complete and partial testosterone deprivation.[/li] [li]However, serum testosterone level was not associated with changes in CEC. In contrast, change in serum 17?-estradiol level exhibited an inverse association with ABCA1-specific efflux (?=-0.48 per 10 pg/mL change in serum 17?-estradiol, p=0.002).[/li] [li]Change in l-HDL-P% correlated inversely with change in serum testosterone level, but positively with change in serum 17?-estradiol level (?=0.50 per 10 pg/mL change in serum 17?-estradiol, p=0.001).[/li] [/ul] Testosterone-mediated changes in serum HDL-C may not reflect changes in HDL CEC. Testosterone and estradiol both may contribute to the regulation of HDL particle size in men. "Testosterone and Estradiol Mediate Discrete Effects on High-density Lipoprotein Particle Size and Sterol Efflux Capacity in Healthy Men," [style=font-style: italic;]Circulation,[/style]2017, 136 [url=http://circ.ahajournals.org/content/136/Suppl_1/A14585]http://circ.ahajournals.org/content/136/Suppl_1/A14585[/url] [/QUOTE]
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Testosterone & E2 Mediate HDL Particle Size
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