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Fig. 1 Schematic representation of the regulation of the HPG axis in healthy and COVID-19 conditions. a Represents the healthy human brain and testes in association with the HPG axis. b Represents a SARS-CoV-2 infected human brain and testes with neuroinflammation and dysregulation of the HPG axis in association with reduced steroidogenesis and spermatogenesis due to testicular inflammation and oxidative stress.

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