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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Test Prop @ 15mg ED/SQ vs Test Cyp @ 20mg ED/SQ... Results.....
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<blockquote data-quote="Cataceous" data-source="post: 214608" data-attributes="member: 38109"><p>If you really want to do it then a loading dose is reasonable, as is overlapping Natesto with the start of injections. Either should reduce the risk of feeling hypogonadal. If you assume a half-life for your enanthate then it's straightforward to calculate a loading dose that in theory leads to immediately having daily testosterone absorption match steady state conditions. In practice it's not so precise, but it probably would still be adequate. The rate of decline of endogenous production is a wildcard, and would be a reason to lower the loading dose a little.</p><p></p><p>I have another post on calculating the loading dose, but it'll be easier to recreate the equations than to track it down. Suppose the half-life in days of your drug is HL. Then the remaining fraction per day is 0.5^(1 / HL). Call this F. For EOD dosing of size D the post-dose residual R of all previous doses at steady state is R = D * (1 + F^2 + F^4 + F^6 +...). Solving yields R = D / (1 - F^2). In other words, your loading dose is R and subsequently you take dose D as usual. For example, if you plan to take 10 mg (D) every other day and the half-life is five days then the first dose for loading (R) is 41 mg.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 214608, member: 38109"] If you really want to do it then a loading dose is reasonable, as is overlapping Natesto with the start of injections. Either should reduce the risk of feeling hypogonadal. If you assume a half-life for your enanthate then it's straightforward to calculate a loading dose that in theory leads to immediately having daily testosterone absorption match steady state conditions. In practice it's not so precise, but it probably would still be adequate. The rate of decline of endogenous production is a wildcard, and would be a reason to lower the loading dose a little. I have another post on calculating the loading dose, but it'll be easier to recreate the equations than to track it down. Suppose the half-life in days of your drug is HL. Then the remaining fraction per day is 0.5^(1 / HL). Call this F. For EOD dosing of size D the post-dose residual R of all previous doses at steady state is R = D * (1 + F^2 + F^4 + F^6 +...). Solving yields R = D / (1 - F^2). In other words, your loading dose is R and subsequently you take dose D as usual. For example, if you plan to take 10 mg (D) every other day and the half-life is five days then the first dose for loading (R) is 41 mg. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Test Prop @ 15mg ED/SQ vs Test Cyp @ 20mg ED/SQ... Results.....
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