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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Test ester metabolism and SC injections (everything we knew is wrong?)
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<blockquote data-quote="FunkOdyssey" data-source="post: 276125" data-attributes="member: 44064"><p>Perhaps in cases where T is lower with SC the T has been destroyed by the immune system? I was reading this great paper "New Insights Into Drug Absorption From Oil Depots" which talks about how the immune system is recruited to the site of the injection and can cause inflammation there.</p><p></p><p></p><p>You can draw your own conclusions about whether SC is generally inferior or more problematic based on the sum of anecdotal data. What I'm talking about here is a potential mechanism for the higher E2 that is observed in SOME fraction of people that have compared equal doses of IM and SC injections. If you don't see higher E2 with SC injections, maybe your interstitial fluid doesn't have much esterase, maybe you are injecting into a very thin layer of fat, who knows. </p><p></p><p>Certainly many people people do not see higher E2 with SC injections. I just wanted to understand: when it does happen, how and why?</p><p></p><p>SC does have certain advantages with HCT and the slower release pattern is preferred by some people.</p></blockquote><p></p>
[QUOTE="FunkOdyssey, post: 276125, member: 44064"] Perhaps in cases where T is lower with SC the T has been destroyed by the immune system? I was reading this great paper "New Insights Into Drug Absorption From Oil Depots" which talks about how the immune system is recruited to the site of the injection and can cause inflammation there. You can draw your own conclusions about whether SC is generally inferior or more problematic based on the sum of anecdotal data. What I'm talking about here is a potential mechanism for the higher E2 that is observed in SOME fraction of people that have compared equal doses of IM and SC injections. If you don't see higher E2 with SC injections, maybe your interstitial fluid doesn't have much esterase, maybe you are injecting into a very thin layer of fat, who knows. Certainly many people people do not see higher E2 with SC injections. I just wanted to understand: when it does happen, how and why? SC does have certain advantages with HCT and the slower release pattern is preferred by some people. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Test ester metabolism and SC injections (everything we knew is wrong?)
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