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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Test cream users: Do you feel better with 1x/day or 2X/day application?
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<blockquote data-quote="Fortunate" data-source="post: 204817" data-attributes="member: 42264"><p>A common complaint about cream is that it can give excellent initial results, but guys often feel the benefit does not last very long. As with all forms of TRT, the transition to or from a protocol can cause you to feel a certain way (honeymoon period). Often, guys hop around protocols because they equate honeymoon ending to "something is wrong" and/or, they feel funky on a new protocol and don't give it enough time (guilty as charged - I have done this many times!). This may be part of the cream phenomenon, but with the cream, it seems different, and I wonder if there is something else at play besides the honeymoon ending.</p><p></p><p>I have done a few trials on cream and have experienced the initial benefit followed by a large drop-off. The first time was really great initially, with results fading. Eventually, I ended up feeling anxious and bad. I have a (very non-scientific) theory on why the benefit may be transient. I suspect it may have to do with the drug's half-life. I have seen pharmacokinetic data on testicular cream, but it only goes out to 16 hours. I suspect the half-life may be sufficiently long that you are not close to a trough by the time you apply cream every morning. This would lead to gradual increasing T levels. When they get high enough, you start to feel bad for a variety of reasons (T and metabolites are too high). This may explain why some guys have posted extremely high T levels on the cream.</p><p></p><p>I have noticed feeling anxious and jittery a full 24 hours after using cream, before applying my next dose. I wonder if it would work better if applied over a larger time interval. However, figuring out that interval might be really hard and applying cream at different times each day would be impractical.</p><p></p><p>In any case, this theory may already be out there. I admit I haven't researched it much, but just wanted to share my thoughts.</p></blockquote><p></p>
[QUOTE="Fortunate, post: 204817, member: 42264"] A common complaint about cream is that it can give excellent initial results, but guys often feel the benefit does not last very long. As with all forms of TRT, the transition to or from a protocol can cause you to feel a certain way (honeymoon period). Often, guys hop around protocols because they equate honeymoon ending to "something is wrong" and/or, they feel funky on a new protocol and don't give it enough time (guilty as charged - I have done this many times!). This may be part of the cream phenomenon, but with the cream, it seems different, and I wonder if there is something else at play besides the honeymoon ending. I have done a few trials on cream and have experienced the initial benefit followed by a large drop-off. The first time was really great initially, with results fading. Eventually, I ended up feeling anxious and bad. I have a (very non-scientific) theory on why the benefit may be transient. I suspect it may have to do with the drug's half-life. I have seen pharmacokinetic data on testicular cream, but it only goes out to 16 hours. I suspect the half-life may be sufficiently long that you are not close to a trough by the time you apply cream every morning. This would lead to gradual increasing T levels. When they get high enough, you start to feel bad for a variety of reasons (T and metabolites are too high). This may explain why some guys have posted extremely high T levels on the cream. I have noticed feeling anxious and jittery a full 24 hours after using cream, before applying my next dose. I wonder if it would work better if applied over a larger time interval. However, figuring out that interval might be really hard and applying cream at different times each day would be impractical. In any case, this theory may already be out there. I admit I haven't researched it much, but just wanted to share my thoughts. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Test cream users: Do you feel better with 1x/day or 2X/day application?
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