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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Tesamorelin vs. Ipamorelin?
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<blockquote data-quote="Cataceous" data-source="post: 172427" data-attributes="member: 38109"><p>Never heard of him. This was a reference cited by Curt Moyer in arguing against higher IGF-1 levels.</p><p></p><p>Your reference is pretty much saying the opposite of what you think it is. The monoclonal antibody treatment is for blocking the IGF-1 receptor. Basically if you turn off IGF-1 signaling then you get longer healthspan and lifespan in females.</p><p></p><p style="margin-left: 20px"><strong>The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases<a href="https://www.nature.com/articles/s41467-018-04805-5#ref-CR9" target="_blank">9</a>,<a href="https://www.nature.com/articles/s41467-018-04805-5#ref-CR10" target="_blank">10</a>,<a href="https://www.nature.com/articles/s41467-018-04805-5#ref-CR11" target="_blank">11</a>, though the reason for sex differences in this response remains unresolved.</strong></p></blockquote><p></p>
[QUOTE="Cataceous, post: 172427, member: 38109"] Never heard of him. This was a reference cited by Curt Moyer in arguing against higher IGF-1 levels. Your reference is pretty much saying the opposite of what you think it is. The monoclonal antibody treatment is for blocking the IGF-1 receptor. Basically if you turn off IGF-1 signaling then you get longer healthspan and lifespan in females. [INDENT][B]The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases[URL='https://www.nature.com/articles/s41467-018-04805-5#ref-CR9']9[/URL],[URL='https://www.nature.com/articles/s41467-018-04805-5#ref-CR10']10[/URL],[URL='https://www.nature.com/articles/s41467-018-04805-5#ref-CR11']11[/URL], though the reason for sex differences in this response remains unresolved.[/B][/INDENT] [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Tesamorelin vs. Ipamorelin?
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