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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Tesamorelin vs. Ipamorelin?
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<blockquote data-quote="Cataceous" data-source="post: 172384" data-attributes="member: 38109"><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/" target="_blank">Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans</a></p><p></p><p style="margin-left: 20px"><em>...we monitored for 22 years Ecuadorian subjects with mutations in the growth hormone receptor gene leading to <strong>severe growth hormone receptor (GHR) and IGF-I deficiencies</strong> and combined this information with surveys to identify the cause and age of death for subjects who died before this period. <strong>The individuals with GHR deficiency (GHRD) exhibited only one non-lethal malignancy and no cases of diabetes, in contrast to 17% cancer and 5% diabetes prevalence in the controls.</strong> A possible explanation for the very low incidence of cancer may be revealed by in vitro studies: serum from GHRD subjects reduced DNA breaks but increased apoptosis in human mammary epithelial cells (HMECs) treated with hydrogen peroxide.</em></p> <p style="margin-left: 20px"><em>...</em></p> <p style="margin-left: 20px"><em>Here, we show that the fundamental <strong>link between pro-growth pathways, oxidative stress, age-dependent genomic instability and cellular damage</strong> observed in yeast (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R2" target="_blank">2</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R15" target="_blank">15</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R19" target="_blank">19</a>-<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R21" target="_blank">21</a>), worms and mice (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R5" target="_blank">5</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R6" target="_blank">6</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R22" target="_blank">22</a>-<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R26" target="_blank">26</a>) <strong>is conserved in humans</strong> by reporting on a 22-year monitoring of an Ecuadorian cohort with GHR and IGF-I deficiencies and by investigating the effect of these deficiencies on the cellular response to stress and on markers of cancer and diabetes.</em></p></blockquote><p></p>
[QUOTE="Cataceous, post: 172384, member: 38109"] [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/']Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans[/URL] [INDENT][I]...we monitored for 22 years Ecuadorian subjects with mutations in the growth hormone receptor gene leading to [B]severe growth hormone receptor (GHR) and IGF-I deficiencies[/B] and combined this information with surveys to identify the cause and age of death for subjects who died before this period. [B]The individuals with GHR deficiency (GHRD) exhibited only one non-lethal malignancy and no cases of diabetes, in contrast to 17% cancer and 5% diabetes prevalence in the controls.[/B] A possible explanation for the very low incidence of cancer may be revealed by in vitro studies: serum from GHRD subjects reduced DNA breaks but increased apoptosis in human mammary epithelial cells (HMECs) treated with hydrogen peroxide.[/I][/INDENT] [INDENT][I]...[/I][/INDENT] [INDENT][I]Here, we show that the fundamental [B]link between pro-growth pathways, oxidative stress, age-dependent genomic instability and cellular damage[/B] observed in yeast ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R2']2[/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R15']15[/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R19']19[/URL]-[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R21']21[/URL]), worms and mice ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R5']5[/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R6']6[/URL], [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R22']22[/URL]-[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357623/#R26']26[/URL]) [B]is conserved in humans[/B] by reporting on a 22-year monitoring of an Ecuadorian cohort with GHR and IGF-I deficiencies and by investigating the effect of these deficiencies on the cellular response to stress and on markers of cancer and diabetes.[/I][/INDENT] [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Tesamorelin vs. Ipamorelin?
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