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General Health & Fitness
Health & Wellness
Tendon: Principles of Healing and Repair
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<blockquote data-quote="madman" data-source="post: 234712" data-attributes="member: 13851"><p><em><strong>*While tendon rupture usually corresponds to an acute incident, evidence suggests that chronic degenerative changes are usually present and contribute to the rupture</strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong> More recent histopathological studies have identified tendinosis (chronic degeneration), as the culprit in most cases of tendinopathy</strong></em></strong></em></p><p><em><strong><em><strong></strong></em></strong></em></p><p><em><strong><em><strong><em><strong>*The affected region in tendinosis exhibits structural and cellular changes relative to unaffected tissue. While a healthy tendon is characterized by parallel, wavy, clearly defined bundles of collagen, diseased tissue is recognizable by its lack of alignment or demarcation between neighboring bundles and its increased diameter</strong></em></strong></em></strong></em></p><p><em><strong><em><strong><em><strong></strong></em></strong></em></strong></em></p><p><em><strong><em><strong><em><strong>*On a cellular level, tendinosis is characterized by neovascularization, hypercellularity, and atypical fibroblast proliferation. Tenocytes capable of producing collagen change shape, with their nuclei exhibiting signs of fibrocartilaginous metaplasia</strong></em></strong></em></strong></em></p><p><em><strong><em><strong><em><strong></strong></em></strong></em></strong></em></p><p><em><strong><em><strong><em><strong>*Biomechanically, tendinosis predisposes tendons to rupture</strong></em></strong></em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 234712, member: 13851"] [I][B]*While tendon rupture usually corresponds to an acute incident, evidence suggests that chronic degenerative changes are usually present and contribute to the rupture *[I][B] More recent histopathological studies have identified tendinosis (chronic degeneration), as the culprit in most cases of tendinopathy [I][B]*The affected region in tendinosis exhibits structural and cellular changes relative to unaffected tissue. While a healthy tendon is characterized by parallel, wavy, clearly defined bundles of collagen, diseased tissue is recognizable by its lack of alignment or demarcation between neighboring bundles and its increased diameter *On a cellular level, tendinosis is characterized by neovascularization, hypercellularity, and atypical fibroblast proliferation. Tenocytes capable of producing collagen change shape, with their nuclei exhibiting signs of fibrocartilaginous metaplasia *Biomechanically, tendinosis predisposes tendons to rupture[/B][/I][/B][/I][/B][/I] [/QUOTE]
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General Health & Fitness
Health & Wellness
Tendon: Principles of Healing and Repair
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