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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
TB-500 Dosage Recommendations
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<blockquote data-quote="BigTex" data-source="post: 274158" data-attributes="member: 43589"><p>The GHRH analog known as CJC 1295 w/o the DAC is also know as tetra (4) substituted GRF(1-29) or modified GRF(1-29). All have a half-life probably 30+ minutes.</p><p></p><p><strong>GRF (1-29)</strong></p><p>(Tyr-<strong>Ala</strong>-Asp-Ala-Ile-Phe-Thr-<strong>Asn</strong>-Ser-Tyr-Arg-Lys-Val-Leu-<strong>Gly</strong>-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-<strong>Met</strong>-Ser-Arg-NH2)</p><p></p><p><strong> CJC 1295/tetra substituted GRF (1-29), modified GRF (1-29)</strong></p><p>(Tyr-<strong>DAla</strong>-Asp-Ala-Ile-Phe-Thr-<strong>Gln</strong>-Ser-Tyr-Arg-Lys-Val-Leu-<strong>Ala</strong>-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-<strong>Leu</strong>-Ser-Arg-NH2) <strong>The 2nd, 8th, 15th & 27th amino acids have been replaced or modified.</strong></p><p></p><p>[URL unfurl="true"]https://www.deepdyve.com/lp/wiley/potent-trypsin-resistant-hgh-rh-analogues-VH3vPOOUuI[/URL]</p><p></p><p>Here is the history of this peptide: The Chinese started selling this product as CJC 1295 without DAC because the DAC product came out first. Scientifically it is known as tetra substituted GRF(1-29) because the GRF 1-29 amino acid sequence has been modified at the 2nd, 8th, 15th & 27th amino acids. DatBTrue came along later on and coined the name modified GRF (1-29). When we 1st started getting peptides from the Chinese back in 2005, all of it was CJC 1295 with the DAC (drug affinity complex). This came out in the early 2000's and the modified version came out around 2005. Prior to 2000 the only ones available were:</p><p></p><p><strong>GRF(1-44)</strong> - half life of ~5 min</p><p><strong>GRF(1-29)</strong> aka <strong>Sermorelin - </strong>half life of <10 min</p><p></p><p>Some really smart guys figured out how to replace the 2nd amino acid Alanine w/ D-Alanine in GRF(1-29) to increase the half-lift to 10 minutes and called it <strong>D-Ala2 GRF(1-29). </strong>So that began the process of substituted amino acids to increase the half-life. Along came the Drug Affinity Complex(DAC) which is a delivery technology developed by ConjuChem in order to protect peptides from rapid degrading and metabolism by the kidneys. DAC is able to extend the half life of GRF (1-29) from <10 min, up to 7 days.</p></blockquote><p></p>
[QUOTE="BigTex, post: 274158, member: 43589"] The GHRH analog known as CJC 1295 w/o the DAC is also know as tetra (4) substituted GRF(1-29) or modified GRF(1-29). All have a half-life probably 30+ minutes. [B]GRF (1-29)[/B] (Tyr-[B]Ala[/B]-Asp-Ala-Ile-Phe-Thr-[B]Asn[/B]-Ser-Tyr-Arg-Lys-Val-Leu-[B]Gly[/B]-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-[B]Met[/B]-Ser-Arg-NH2) [B] CJC 1295/tetra substituted GRF (1-29), modified GRF (1-29)[/B] (Tyr-[B]DAla[/B]-Asp-Ala-Ile-Phe-Thr-[B]Gln[/B]-Ser-Tyr-Arg-Lys-Val-Leu-[B]Ala[/B]-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-[B]Leu[/B]-Ser-Arg-NH2) [B]The 2nd, 8th, 15th & 27th amino acids have been replaced or modified.[/B] [URL unfurl="true"]https://www.deepdyve.com/lp/wiley/potent-trypsin-resistant-hgh-rh-analogues-VH3vPOOUuI[/URL] Here is the history of this peptide: The Chinese started selling this product as CJC 1295 without DAC because the DAC product came out first. Scientifically it is known as tetra substituted GRF(1-29) because the GRF 1-29 amino acid sequence has been modified at the 2nd, 8th, 15th & 27th amino acids. DatBTrue came along later on and coined the name modified GRF (1-29). When we 1st started getting peptides from the Chinese back in 2005, all of it was CJC 1295 with the DAC (drug affinity complex). This came out in the early 2000's and the modified version came out around 2005. Prior to 2000 the only ones available were: [B]GRF(1-44)[/B] - half life of ~5 min [B]GRF(1-29)[/B] aka [B]Sermorelin - [/B]half life of <10 min Some really smart guys figured out how to replace the 2nd amino acid Alanine w/ D-Alanine in GRF(1-29) to increase the half-lift to 10 minutes and called it [B]D-Ala2 GRF(1-29). [/B]So that began the process of substituted amino acids to increase the half-life. Along came the Drug Affinity Complex(DAC) which is a delivery technology developed by ConjuChem in order to protect peptides from rapid degrading and metabolism by the kidneys. DAC is able to extend the half life of GRF (1-29) from <10 min, up to 7 days. [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
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