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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Targeting of PDE5 for Preservation of Penile Health
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<blockquote data-quote="madman" data-source="post: 218504" data-attributes="member: 13851"><p><strong>Figure 1. <u>Schematic diagram of the nitric oxide (NO) signaling pathway in the penis in the context of normal erection physiology</u>. The diagram shows the molecular determinants of a regulatory balance that governs alternative physiologic states of erectile tissue relaxation (erection) and erectile tissue contraction (flaccidity). NO, generated constitutively from L-arginine and released from nerves and endothelium, diffuses to local smooth muscle cells where it primarily activates guanylate cyclase to convert 59-guanosine triphosphate (GTP) to 39,59-cyclic guanosine monophosphate (cGMP). By way of cGMP-dependent downstream effector molecule actions, cGMP elicits penile erection. The catalytic function of phosphodiesterase type 5 accounts for the degradation of cGMP to its inactive form, 59-GMP, with the subsequent reformation of GTP.</strong></p><p><strong>[ATTACH=full]19956[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 218504, member: 13851"] [B]Figure 1. [U]Schematic diagram of the nitric oxide (NO) signaling pathway in the penis in the context of normal erection physiology[/U]. The diagram shows the molecular determinants of a regulatory balance that governs alternative physiologic states of erectile tissue relaxation (erection) and erectile tissue contraction (flaccidity). NO, generated constitutively from L-arginine and released from nerves and endothelium, diffuses to local smooth muscle cells where it primarily activates guanylate cyclase to convert 59-guanosine triphosphate (GTP) to 39,59-cyclic guanosine monophosphate (cGMP). By way of cGMP-dependent downstream effector molecule actions, cGMP elicits penile erection. The catalytic function of phosphodiesterase type 5 accounts for the degradation of cGMP to its inactive form, 59-GMP, with the subsequent reformation of GTP. [ATTACH type="full" alt="Screenshot (11172).png"]19956[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Targeting of PDE5 for Preservation of Penile Health
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