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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Target T levels & Defy
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<blockquote data-quote="tareload" data-source="post: 222778"><p>As [USER=38109]@Cataceous[/USER] mentioned I transformed the y-axis to logarithmic scale. Here's the plot generated from 2018 paper on linear ordinate scale:</p><p><img src="https://aws1.discourse-cdn.com/tnation/uploads/default/original/4X/8/6/8/8685e3da627b88813a5c160c3a57b8b59e50ea86.png" class="bbImage" alt="" data-url="https://aws1.discourse-cdn.com/tnation/uploads/default/original/4X/8/6/8/8685e3da627b88813a5c160c3a57b8b59e50ea86.png" style="" /></p><p></p><p></p><p>Dose response is very linear and I put the linear regression equations on the graph for the reader.</p><p></p><p>Now here's the same plot with "highpull's data" on the linear y-axis:</p><p>[ATTACH=full]21602[/ATTACH]</p><p></p><p>Here it is again with the transformed log scale:</p><p></p><p><img src="https://aws1.discourse-cdn.com/tnation/uploads/default/optimized/4X/1/0/b/10be4e1c3236578ce0d468e5eba9ace2122aa4d2_2_690x484.png" class="bbImage" alt="" data-url="https://aws1.discourse-cdn.com/tnation/uploads/default/optimized/4X/1/0/b/10be4e1c3236578ce0d468e5eba9ace2122aa4d2_2_690x484.png" style="" /></p><p>Observe "highpull"'s data set falls almost exclusively within the 2.5-97.5 percentile region as you might expect if the 2018 paper correctly sampled from a population of men with various rate of fT elimination. In fact since the sample size for each dosage was on the low side they had to estimate the confidence intervals using a <a href="https://garstats.wordpress.com/2019/07/25/boott/" target="_blank">bootstrap t-scoring method</a>):</p><p></p><p>[URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/29436172/[/URL]</p><p>[ATTACH=full]21603[/ATTACH]</p><p></p><p>[ATTACH=full]21604[/ATTACH]</p><p></p><p></p><p>Why did I use log-scale? So I could make the region from 100-1,000 ng/dl take up the same area as the region from 1000 to 10,000 ng/dl. Let's the reader get a different zoomed-in view of the physiologic region. Also shows the absurdity of the debate I stupidly get in routinely with TOT apologists where they claim 150-175 mg/week of test ester is the <em>minimum starting dose</em> to get the in the door at <em>Club "Optimization"</em>.</p><p></p><p>Note: I also did the same analysis using Bhasin's seminal work which provides stratification by patient age (old vs young):</p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/what-is-trt-and-what-is-not-trt.22188/post-222084[/URL]</p></blockquote><p></p>
[QUOTE="tareload, post: 222778"] As [USER=38109]@Cataceous[/USER] mentioned I transformed the y-axis to logarithmic scale. Here's the plot generated from 2018 paper on linear ordinate scale: [IMG]https://aws1.discourse-cdn.com/tnation/uploads/default/original/4X/8/6/8/8685e3da627b88813a5c160c3a57b8b59e50ea86.png[/IMG] Dose response is very linear and I put the linear regression equations on the graph for the reader. Now here's the same plot with "highpull's data" on the linear y-axis: [ATTACH type="full" alt="1651324927170.png"]21602[/ATTACH] Here it is again with the transformed log scale: [IMG]https://aws1.discourse-cdn.com/tnation/uploads/default/optimized/4X/1/0/b/10be4e1c3236578ce0d468e5eba9ace2122aa4d2_2_690x484.png[/IMG] Observe "highpull"'s data set falls almost exclusively within the 2.5-97.5 percentile region as you might expect if the 2018 paper correctly sampled from a population of men with various rate of fT elimination. In fact since the sample size for each dosage was on the low side they had to estimate the confidence intervals using a [URL='https://garstats.wordpress.com/2019/07/25/boott/']bootstrap t-scoring method[/URL]): [URL unfurl="true"]https://pubmed.ncbi.nlm.nih.gov/29436172/[/URL] [ATTACH type="full" alt="1651325650489.png"]21603[/ATTACH] [ATTACH type="full" alt="1651326545849.png"]21604[/ATTACH] Why did I use log-scale? So I could make the region from 100-1,000 ng/dl take up the same area as the region from 1000 to 10,000 ng/dl. Let's the reader get a different zoomed-in view of the physiologic region. Also shows the absurdity of the debate I stupidly get in routinely with TOT apologists where they claim 150-175 mg/week of test ester is the [I]minimum starting dose[/I] to get the in the door at [I]Club "Optimization"[/I]. Note: I also did the same analysis using Bhasin's seminal work which provides stratification by patient age (old vs young): [URL unfurl="true"]https://www.excelmale.com/forum/threads/what-is-trt-and-what-is-not-trt.22188/post-222084[/URL] [/QUOTE]
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