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Testosterone Replacement, Low T, HCG, & Beyond
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Target Free T Levels
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<blockquote data-quote="Fortunate" data-source="post: 230437" data-attributes="member: 42264"><p>The reason I started this thread was because I was experiencing crushing fatigue and was trying to figure why I had it and what I could do to reverse it (thus, the question of how high I can/should push my fT). </p><p></p><p>The fatigue was significant and prolonged - I am not used to feeling that tired for so long. I was really confident that I "crashed" my E2, as I had been taking 0.125mg of anastrazole around the time of each injection for about three weeks. So, I got labs, posted above, but didn't have my ultrasensitive estradiol, until today, and I wanted to post feedback.....</p><p></p><p>Convinced the level was going to be undetectable or something, I opened my labs and my estradiol is (drumroll....) 39 (normal is <29)!</p><p></p><p>Wow, was I surprised! Crashed E2 could not explain my conundrum. And, while some are really sensitive to even slightly elevated E2, I really doubt that a level of 39 could be the culprit of all this fatigue (although, I suppose it's still possible - but is at the bottom of my list). A day or two before getting the labs back, I started thinking about other possible culprits (I am not anemic and I have no reason to have a brand new thyroid disorder), and my next choice was nebivolol (Bystolic).</p><p></p><p>Beta blockers are known to cause fatigue, depression, sluggish thinking, etc. I switched from propranolol to nebivolol for this very reason. It didn't occur to me that this could be nebivolol because I had been on it for a while in the past and restarted it a full three weeks prior to the onset of the fatigue. That said, I happened to request brand name Bystolic over generic nebivolol because I didn't think the generic was as effective. My fatigue started about two weeks after that!</p><p></p><p>Two nights ago, I dropped my nebivolol dose from 5mg to 2.5mg. Yesterday, I still had some fatigue, but it was significantly less than usual. As of now, I am pretty convinced the Bystolic was the issue all along, which really surprised me. I plan to continue at the lower dose and watch. If the issues persist, I will try to wean off it altogether, which is a bummer, because I do appreciate the benefits.</p><p></p><p>It's funny, while on TRT, we (or, at least I) tend to get so focused on hormones and how they are impacting every aspect of our lives. This little story is a reminder to me that hormones are neither the source of nor are they the solution to all my woes.</p><p></p><p>As an aside, it is interesting that my E2 was high despite using anastrazole on a fairly regular basis. I still doubt high E2 is the issue and plan to ignore it for the time being while I see how things go on the lower dose of nebivolol.</p><p></p><p>I will post more as I learn more.</p></blockquote><p></p>
[QUOTE="Fortunate, post: 230437, member: 42264"] The reason I started this thread was because I was experiencing crushing fatigue and was trying to figure why I had it and what I could do to reverse it (thus, the question of how high I can/should push my fT). The fatigue was significant and prolonged - I am not used to feeling that tired for so long. I was really confident that I "crashed" my E2, as I had been taking 0.125mg of anastrazole around the time of each injection for about three weeks. So, I got labs, posted above, but didn't have my ultrasensitive estradiol, until today, and I wanted to post feedback..... Convinced the level was going to be undetectable or something, I opened my labs and my estradiol is (drumroll....) 39 (normal is <29)! Wow, was I surprised! Crashed E2 could not explain my conundrum. And, while some are really sensitive to even slightly elevated E2, I really doubt that a level of 39 could be the culprit of all this fatigue (although, I suppose it's still possible - but is at the bottom of my list). A day or two before getting the labs back, I started thinking about other possible culprits (I am not anemic and I have no reason to have a brand new thyroid disorder), and my next choice was nebivolol (Bystolic). Beta blockers are known to cause fatigue, depression, sluggish thinking, etc. I switched from propranolol to nebivolol for this very reason. It didn't occur to me that this could be nebivolol because I had been on it for a while in the past and restarted it a full three weeks prior to the onset of the fatigue. That said, I happened to request brand name Bystolic over generic nebivolol because I didn't think the generic was as effective. My fatigue started about two weeks after that! Two nights ago, I dropped my nebivolol dose from 5mg to 2.5mg. Yesterday, I still had some fatigue, but it was significantly less than usual. As of now, I am pretty convinced the Bystolic was the issue all along, which really surprised me. I plan to continue at the lower dose and watch. If the issues persist, I will try to wean off it altogether, which is a bummer, because I do appreciate the benefits. It's funny, while on TRT, we (or, at least I) tend to get so focused on hormones and how they are impacting every aspect of our lives. This little story is a reminder to me that hormones are neither the source of nor are they the solution to all my woes. As an aside, it is interesting that my E2 was high despite using anastrazole on a fairly regular basis. I still doubt high E2 is the issue and plan to ignore it for the time being while I see how things go on the lower dose of nebivolol. I will post more as I learn more. [/QUOTE]
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