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Elevated hemoglobin, hematocrit and estradiol are some of the obvious side effects of too much testosterone. Excess fluid retention is another, and then there are the possible influences on dopamine, prolactin, thyroid function and the HPA. Philosophically the issue is about choosing realistic serum testosterone so that the unintended consequences of excess are avoided. In my opinion two main facets can explain most of the problems guys have with TRT: first is excessive dosing and the lack of diurnal variation; second is the suppression of upstream hormones.