T\E Ratio

They are taking about E/T not T/E ratios :)

Here is the one about T/E

EVIDENCE OF A TREATABLE ENDOCRINOPATHY IN INFERTILE MEN The Journal of Urology Volume 165, Issue 3, March 2001, Pages 837–841


Purpose We establish whether a subset of infertile men have decreased serum testosterone-to-estradiol ratios and whether this condition can be corrected with an oral aromatase inhibitor. Materials and Methods The serum testosterone-to-estradiol ratios of 63 men with severe male factor infertility or hypergonadotropic hypogonadism (mean follicle-stimulating hormone 21.2 ± 1.8) were compared with those of an age matched, fertile, control reference group. Of the 63 men 43 were azoospermic with biopsy proved severe male infertility and 20 were oligospermic. The men with the lowest ratios (less than 20th percentile) were treated with 50 to 100 mg. of the aromatase inhibitor testolactone orally twice daily. Testosterone-to-estradiol ratios and semen analyses were evaluated during testolactone therapy. Results Men with severe male infertility had significantly lower testosterone (328 versus 543 ng./dl., p <0.01) and higher estradiol (58.4 versus 43.5 ng./l., p = 0.01) than fertile control reference subjects, resulting in a decreased testosterone-to-estradiol ratio (×10−1 = 6.9 ± 0.6 versus 14.5 ± 1.2, respectively, p <0.01). Of the 45 men treated with testolactone a correction of these abnormalities was seen and ratios (×10−1) increased into the normal range (5.0 ± 0.3 to 12.7 ± 1.2, p <0.01). Semen analyses were considered evaluable only in men with sperm in the ejaculate before aromatase inhibitor treatment. Semen analyses before and during testolactone treatment revealed significant increases in sperm concentration (16.1 to 28.9 million sperm per ml., p = 0.03) and motility (27.1% to 45.3%, p <0.01) in 12 oligospermic men. Conclusions We identified an endocrinopathy in men with severe male factor infertility that is characterized by a decreased serum testosterone-to-estradiol ratio. This ratio can be corrected by aromatase inhibition, resulting in a significant improvement in semen parameters in oligospermic patients. T/E2 Ratios:


testosterone to estradiol ratio.gif

Read more at: https://www.excelmale.com/forum/sho...tosterone-to-Estradiol-Ratio-Important-in-Men
 
Can someone points to the study that point to the 14-20:1 ratio

The ratio you quote has been developed by leading androgen researchers who hold that it is a valid metric that can be used to evaluate testosterone and estradiol levels. However, it has not been subjected to large scale study.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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