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Very little data on T/E2 ratios (that actually use LC/MS for both parameters).

My hypothesis is that, like all hormones, there is an inverted U-shaped curve (for benefits vs T/E2 ratio). Some studies hint at T/E2 above 14, but we have no data on the upper range since very high T/E2 may be indicative of low estradiol.

Post #12: Is Testosterone to Estradiol Ratio Important in Men?

Since 0.3 percent of TT is normally aromatized into E2 in healthy men, then it makes sense that

1/0.03= 33 should be used as a benchmark

Estradiol tends to plateau as T dose increases (probably also due to increased DHT that acts as an estradiol blocker). Aromatization was shown to be higher for older men here:

Effect of Testosterone Injections on Estradiol and DHT in Young and Older Men - ExcelMale

I think 0.25 mg per week of anastrozole makes sense for men whose conversion is above 0.3 percent (I think we should monitor estradiol like we do free T. Free T percent should be 2% of TT or above). DHT should be 10% of TT or above.

<blockquote data-quote="Nelson Vergel" data-source="post: 136584" data-attributes="member: 3">Very little data on T/E2 ratios (that actually use LC/MS for both parameters).

My hypothesis is that, like all hormones, there is an inverted U-shaped curve (for benefits vs T/E2 ratio). Some studies hint at T/E2 above 14, but we have no data on the upper range since very high T/E2 may be indicative of low estradiol.

Post #12: <a href="https://www.excelmale.com/forum/threads/is-testosterone-to-estradiol-ratio-important-in-men.4921/" target="_blank">Is Testosterone to Estradiol Ratio Important in Men?</a>

Since 0.3 percent of TT is normally aromatized into E2 in healthy men, then it makes sense that

1/0.03= 33 should be used as a benchmark

Estradiol tends to plateau as T dose increases (probably also due to increased DHT that acts as an estradiol blocker). Aromatization was shown to&nbsp; be higher for older men here:

<a href="https://www.excelmale.com/effect-of-testosterone-injections-on-estradiol-and-dht-in-young-and-older-men/" target="_blank">Effect of Testosterone Injections on Estradiol and DHT in Young and Older Men - ExcelMale</a>

I think 0.25 mg per week of anastrozole makes sense for men whose conversion is above 0.3 percent (I think we should monitor estradiol like we do free T. Free T percent should be 2% of TT or above). DHT should be 10% of TT or above.</blockquote>

[QUOTE="Nelson Vergel, post: 136584, member: 3"] [INDENT]Very little data on T/E2 ratios (that actually use LC/MS for both parameters). My hypothesis is that, like all hormones, there is an inverted U-shaped curve (for benefits vs T/E2 ratio). Some studies hint at T/E2 above 14, but we have no data on the upper range since very high T/E2 may be indicative of low estradiol. Post #12: [URL="https://www.excelmale.com/forum/threads/is-testosterone-to-estradiol-ratio-important-in-men.4921/"]Is Testosterone to Estradiol Ratio Important in Men?[/URL] Since 0.3 percent of TT is normally aromatized into E2 in healthy men, then it makes sense that 1/0.03= 33 should be used as a benchmark Estradiol tends to plateau as T dose increases (probably also due to increased DHT that acts as an estradiol blocker). Aromatization was shown to be higher for older men here: [URL="https://www.excelmale.com/effect-of-testosterone-injections-on-estradiol-and-dht-in-young-and-older-men/"]Effect of Testosterone Injections on Estradiol and DHT in Young and Older Men - ExcelMale[/URL] I think 0.25 mg per week of anastrozole makes sense for men whose conversion is above 0.3 percent (I think we should monitor estradiol like we do free T. Free T percent should be 2% of TT or above). DHT should be 10% of TT or above.[/INDENT] [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038