Very little data on T/E2 ratios (that actually use LC/MS for both parameters).
My hypothesis is that, like all hormones, there is an inverted U-shaped curve (for benefits vs T/E2 ratio). Some studies hint at T/E2 above 14, but we have no data on the upper range since very high T/E2 may be indicative of low estradiol.
Post #12: Is Testosterone to Estradiol Ratio Important in Men?
Since 0.3 percent of TT is normally aromatized into E2 in healthy men, then it makes sense that
1/0.03= 33 should be used as a benchmark
Estradiol tends to plateau as T dose increases (probably also due to increased DHT that acts as an estradiol blocker). Aromatization was shown to be higher for older men here:
Effect of Testosterone Injections on Estradiol and DHT in Young and Older Men - ExcelMale
I think 0.25 mg per week of anastrozole makes sense for men whose conversion is above 0.3 percent (I think we should monitor estradiol like we do free T. Free T percent should be 2% of TT or above). DHT should be 10% of TT or above.