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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
T.Cyp 100 mg/week - Night sweats, anxiety
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<blockquote data-quote="madman" data-source="post: 266832" data-attributes="member: 13851"><p><strong><em> With esters like cypionate , and enanthate you don’t need to inject more often. The problem with more often injections is that your levels are always peaked.</em></strong></p><p></p><p>The peak--->trough is clipped/minimized when injecting TC/TE daily.</p><p></p><p>Many jump on dailies thinking it will help lower estradiol let alone hematocrit.</p><p></p><p>Unfortunately, this is not a given because the main issue as to why many still struggle when injecting daily is that they are still running too high an FT level.</p><p></p><p>It's not just peak vs trough here as running too high a FT level steady state can lead to numerous issues/sides.</p><p></p><p>The goal of injecting daily would be using the lowest weekly dose that would allow one to hit/maintain a healthy FT level in order to reap the beneficial effects while at the same time minimizing/preventing sides.</p><p></p><p>Easier said than done.</p><p></p><p></p><p></p><p></p><p><strong><em>The body needs fluctuations. Injecting every day or every other day does not mimic natural production at all.</em></strong></p><p></p><p>Definitely agree that fluctuations in T whether daily when using nasal T gel (Natesto), oral TU (Jatenzo, Tlando, Kyzatrex), or even TP let alone fluctuations throughout the week when injecting TC or TE once weekly/twice weekly can be advantageous for many.</p><p></p><p>Even then injecting TC/TE daily or EOD let alone TP daily in no way mimics the natural endogenous 24-hour circadian rhythm of a healthy young male.</p><p></p><p>If anything with daily TP you are just hitting a daily peak/trough and most could never follow an injection schedule to hit the natty peak which is in the early AM let alone TP will result in T levels rising too fast post-injection as opposed to natty T levels which gradually rise throughout the night.</p><p></p><p>Even though TC/TE/TP have different PKs mind you TC/TE are basically interchangeable there will be an initial burst release of T within the first 2 hours post-injection with such esters.</p><p></p><p>No TRT formulation other than the T-patch (Androderm) applied before bed most closely mimics the natural endogenous 24-hour circadian rhythm of a healthy young male.</p><p></p><p></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/so-who-is-happy-with-trt-who-wish-they-never-started.28493/page-2#post-265125[/URL]</p><p></p><p></p><p>Many fail to realize that T levels gradually rise overnight reaching peak in the early AM.</p><p></p><p><strong>*<em><strong><u>ele</u></strong><u>vated and near peak TT level during nighttime sleep</u>, peak TT level around the time of morning awakening</em></strong></p><p></p><p><em><em><strong>*<u>T production occurs in the greatest amount during sleep</u> as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males (91).</strong></em></em></p><p></p><p></p><p></p><p></p><p>This is key:</p><p></p><p><strong><em>(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. <u>Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, closely mimics the TT circadian rhythm of normal young adult males</u>.</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/oral-testosterone-vs-daily-cyp-prop-injection.28594/#post-266524[/URL]</p><p></p><p></p><p></p><p></p><p></p><p></p><p>The Internet is loaded with such.</p><p></p><p>Many are left in a constant state of confusion.</p><p></p><p>This is what happens when people waste all of their time on some of those other so-called HRT forums let alone gootube flooded with these so-called testosterone GURUs!</p></blockquote><p></p>
[QUOTE="madman, post: 266832, member: 13851"] [B][I] With esters like cypionate , and enanthate you don’t need to inject more often. The problem with more often injections is that your levels are always peaked.[/I][/B] The peak--->trough is clipped/minimized when injecting TC/TE daily. Many jump on dailies thinking it will help lower estradiol let alone hematocrit. Unfortunately, this is not a given because the main issue as to why many still struggle when injecting daily is that they are still running too high an FT level. It's not just peak vs trough here as running too high a FT level steady state can lead to numerous issues/sides. The goal of injecting daily would be using the lowest weekly dose that would allow one to hit/maintain a healthy FT level in order to reap the beneficial effects while at the same time minimizing/preventing sides. Easier said than done. [B][I]The body needs fluctuations. Injecting every day or every other day does not mimic natural production at all.[/I][/B] Definitely agree that fluctuations in T whether daily when using nasal T gel (Natesto), oral TU (Jatenzo, Tlando, Kyzatrex), or even TP let alone fluctuations throughout the week when injecting TC or TE once weekly/twice weekly can be advantageous for many. Even then injecting TC/TE daily or EOD let alone TP daily in no way mimics the natural endogenous 24-hour circadian rhythm of a healthy young male. If anything with daily TP you are just hitting a daily peak/trough and most could never follow an injection schedule to hit the natty peak which is in the early AM let alone TP will result in T levels rising too fast post-injection as opposed to natty T levels which gradually rise throughout the night. Even though TC/TE/TP have different PKs mind you TC/TE are basically interchangeable there will be an initial burst release of T within the first 2 hours post-injection with such esters. No TRT formulation other than the T-patch (Androderm) applied before bed most closely mimics the natural endogenous 24-hour circadian rhythm of a healthy young male. [URL unfurl="true"]https://www.excelmale.com/forum/threads/so-who-is-happy-with-trt-who-wish-they-never-started.28493/page-2#post-265125[/URL] Many fail to realize that T levels gradually rise overnight reaching peak in the early AM. [B]*[I][B][U]ele[/U][/B][U]vated and near peak TT level during nighttime sleep[/U], peak TT level around the time of morning awakening[/I][/B] [I][I][B]*[U]T production occurs in the greatest amount during sleep[/U] as recurring pulses at approximately 90 min intervals in healthy young males and approximately 140 min in healthy middle-aged males (91).[/B][/I][/I] This is key: [B][I](i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. [U]Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, closely mimics the TT circadian rhythm of normal young adult males[/U].[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/oral-testosterone-vs-daily-cyp-prop-injection.28594/#post-266524[/URL] The Internet is loaded with such. Many are left in a constant state of confusion. This is what happens when people waste all of their time on some of those other so-called HRT forums let alone gootube flooded with these so-called testosterone GURUs! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
T.Cyp 100 mg/week - Night sweats, anxiety
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