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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
T.Cyp 100 mg/week - Night sweats, anxiety
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<blockquote data-quote="madman" data-source="post: 265733" data-attributes="member: 13851"><p><strong><em>I tried 3xweek, now 2xweek, my goal is to do it once a week, so I can minimize the number of injections. I don't mind doing it, but I worry about the next 25 years. Will I still like it?</em></strong></p><p><strong><em></em></strong></p><p><strong><em>So once I complete 8 weeks on this protocol, and have my labs, I'll evaluate vs the previous 3xWeek and probably test drive 1xWeek.</em></strong></p><p></p><p>You need to give your current protocol a fighting chance (12 weeks) before jumping into switching up your protocol (dose of T/injection frequency).</p><p></p><p>Again it will take a few months for the body to adapt to your new set-point after blood levels have stabilized (4-6 weeks TC/TE).</p><p></p><p></p><p></p><p></p><p><strong><em>My doctor said that in order to keep HCT down, frequency needed to be increased. I'm glad to see a counter-example.</em></strong></p><p></p><p>This is far from a given and I would put more weight behind where your trough FT levels sits.</p><p></p><p>Many make the mistake of jumping on more frequent injections in the hopes of bringing down hematocrit let alone estradiol yet they end up running into issues because they are still running high/absurdly high trough FT levels on dailies.</p><p></p><p>Running high/absurdly high FT levels let alone at the trough than it is a given that you are going to drive up your RBCs, hemoglobin and hematocrit.</p><p></p><p>Top it all off that 8 weeks in when first starting TRT let alone tweaking a protocol (increasing dose of T/injection frequency) means nothing when looking at the bigger picture as it will take anywhere from 6-9 months and in some cases up to a year for hematocrit to reach peak levels.</p><p></p><p>Where your hematocrit sits 6-8 weeks in is not where it is going to end up 6-12 months later.</p><p></p><p>Many fail to realize this and end up scratching there heads down the road.</p><p></p><p>This is why hematocrit is tested at 3, 6, 9 and 12 months when first starting TRT.</p><p></p><p>After that it is twice or in some cases once yearly on a stable protocol.</p><p></p><p>If you keep messing with your protocol especially increasing the T dose than you need to restart this whole process over again!</p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/management-of-erythrocytosis-during-trt.28358/[/URL]</p><p></p><p>This needs to be stressed!</p><p></p><p>Patience is key when tweaking a protocol (decreasing/increasing T dose).</p><p></p><p></p><p><strong><em>*It has to be noted that the largest increase in hematocrit levels is seen in the first year after initiation of testosterone therapy. On the other hand it is expected that a decrease can take a similar amount of time. Especially when taking into account that the lifespan of a erythrocyte is 120 days. Hence, interventions to lower hematocrit levels should be evaluated after 6 months and a decrease can be expected until 1 year after the intervention.</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/i-am-on-week-5-6-anxiety-comes-and-goes.26229/page-2#post-240508[/URL]</p><p></p><p><strong>Regarding those struggling with <a href="https://www.discountedlabs.com/blog/what-you-should-know-about-the-main-side-effect-of-testosterone" target="_blank">high hematocrit</a> here is my reply from another thread:</strong></p><p></p><p>As you can see your RBCs/hemoglobin/hematocrit is elevated which is a common side-effect when using exogenous T, especially when running higher FT levels let alone peak--->trough levels can have a significant impact.</p><p></p><p>When using exogenous T RBCs, hemoglobin and hematocrit will increase within the 1st month and can take anywhere from 6-12 months to reach peak levels.</p><p></p><p>T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit).</p><p></p><p>Other factors such as sleep apnea, smoking, asthma, COPD can have a negative impact on hematocrit.</p><p></p><p>Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T.</p><p></p><p>3–18% with transdermal administration and up to 44% with injection.</p><p></p><p>In most cases when using injectable T <u><strong><em>high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level)</em></strong></u> will have a big impact on increasing HCT.</p><p></p><p>Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given.</p><p></p><p><strong><em>As again </em></strong><em><strong>running very high TT/FT levels will have a stronger impact on driving up HCT.</strong></em></p><p></p><p>Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that <em><strong>the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.</strong></em></p><p></p><p>Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels.</p><p></p><p><strong><em>How high an FT level you are running is critical.</em></strong></p><p></p><p>It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are <em><strong>running too high an FT level</strong></em><strong><em>.</em></strong></p><p></p><p>Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such.</p><p></p><p>If you are struggling with such blood markers then in most cases finding the<em><strong> lowest FT level you can run while still maintaining the beneficial effects </strong></em>may very well be the solution.</p><p></p><p>Easier said than done as many men on trt tend to do better running higher-end FT levels within reason.</p><p></p><p>Mind you some are lucky and never have an issue or levels tend to stabilize over time.</p><p></p><p>Others will continue to struggle until the cows come home.</p><p></p><p>Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube!</p></blockquote><p></p>
[QUOTE="madman, post: 265733, member: 13851"] [B][I]I tried 3xweek, now 2xweek, my goal is to do it once a week, so I can minimize the number of injections. I don't mind doing it, but I worry about the next 25 years. Will I still like it? So once I complete 8 weeks on this protocol, and have my labs, I'll evaluate vs the previous 3xWeek and probably test drive 1xWeek.[/I][/B] You need to give your current protocol a fighting chance (12 weeks) before jumping into switching up your protocol (dose of T/injection frequency). Again it will take a few months for the body to adapt to your new set-point after blood levels have stabilized (4-6 weeks TC/TE). [B][I]My doctor said that in order to keep HCT down, frequency needed to be increased. I'm glad to see a counter-example.[/I][/B] This is far from a given and I would put more weight behind where your trough FT levels sits. Many make the mistake of jumping on more frequent injections in the hopes of bringing down hematocrit let alone estradiol yet they end up running into issues because they are still running high/absurdly high trough FT levels on dailies. Running high/absurdly high FT levels let alone at the trough than it is a given that you are going to drive up your RBCs, hemoglobin and hematocrit. Top it all off that 8 weeks in when first starting TRT let alone tweaking a protocol (increasing dose of T/injection frequency) means nothing when looking at the bigger picture as it will take anywhere from 6-9 months and in some cases up to a year for hematocrit to reach peak levels. Where your hematocrit sits 6-8 weeks in is not where it is going to end up 6-12 months later. Many fail to realize this and end up scratching there heads down the road. This is why hematocrit is tested at 3, 6, 9 and 12 months when first starting TRT. After that it is twice or in some cases once yearly on a stable protocol. If you keep messing with your protocol especially increasing the T dose than you need to restart this whole process over again! [URL unfurl="true"]https://www.excelmale.com/forum/threads/management-of-erythrocytosis-during-trt.28358/[/URL] This needs to be stressed! Patience is key when tweaking a protocol (decreasing/increasing T dose). [B][I]*It has to be noted that the largest increase in hematocrit levels is seen in the first year after initiation of testosterone therapy. On the other hand it is expected that a decrease can take a similar amount of time. Especially when taking into account that the lifespan of a erythrocyte is 120 days. Hence, interventions to lower hematocrit levels should be evaluated after 6 months and a decrease can be expected until 1 year after the intervention.[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/i-am-on-week-5-6-anxiety-comes-and-goes.26229/page-2#post-240508[/URL] [B]Regarding those struggling with [URL='https://www.discountedlabs.com/blog/what-you-should-know-about-the-main-side-effect-of-testosterone']high hematocrit[/URL] here is my reply from another thread:[/B] As you can see your RBCs/hemoglobin/hematocrit is elevated which is a common side-effect when using exogenous T, especially when running higher FT levels let alone peak--->trough levels can have a significant impact. When using exogenous T RBCs, hemoglobin and hematocrit will increase within the 1st month and can take anywhere from 6-12 months to reach peak levels. T formulation, the dose of T, genetics (polymorphism of the AR), age all play a role in the impact a trt protocol will have on blood markers (RBCs/hemoglobin/hematocrit). Other factors such as sleep apnea, smoking, asthma, COPD can have a negative impact on hematocrit. Injectable T has been shown to have a greater impact on increasing HCT compared to transdermal T. 3–18% with transdermal administration and up to 44% with injection. In most cases when using injectable T [U][B][I]high supra-physiological peaks post-injection and overall T levels (running too high TT/FT level)[/I][/B][/U] will have a big impact on increasing HCT. Manipulating injection frequency by injecting more frequently using lower doses of T resulting in minimizing the peak--->trough and maintaining more stable levels may lessen the impact on HCT but it is not a given. [B][I]As again [/I][/B][I][B]running very high TT/FT levels will have a stronger impact on driving up HCT.[/B][/I] Although injectables have been shown to have a greater impact on HCT you can see even when using a transdermal formulation that maintains stable serum concentrations that [I][B]the impact it has on HCT is DEPENDANT ON THE DOSE AND SERUM LEVEL OF T.[/B][/I] Using higher doses of transdermal T and achieving higher TT/FT levels will have a great impact on HCT levels. [B][I]How high an FT level you are running is critical.[/I][/B] It is a given that most men on trt struggling with elevated RBCs/hemoglobin/hematocrit are [I][B]running too high an FT level[/B][/I][B][I].[/I][/B] Sure some men are more sensitive than others as they may still struggle with elevated blood markers when running lower T levels but it is far from common and many may already have an underlying health issue contributing to such. If you are struggling with such blood markers then in most cases finding the[I][B] lowest FT level you can run while still maintaining the beneficial effects [/B][/I]may very well be the solution. Easier said than done as many men on trt tend to do better running higher-end FT levels within reason. Mind you some are lucky and never have an issue or levels tend to stabilize over time. Others will continue to struggle until the cows come home. Unfortunately too many are caught up in running absurdly high trough FT levels due to the herd mentality spewed on the bro forums and gootube! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
T.Cyp 100 mg/week - Night sweats, anxiety
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