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That will be my next step, just need to make sure how my body reacts to different schedules. I tried 3xweek, now 2xweek, my goal is to do it once a week, so I can minimize the number of injections. I don't mind doing it, but I worry about the next 25 years. Will I still like it?

So once I complete 8 weeks on this protocol, and have my labs, I'll evaluate vs the previous 3xWeek and probably test drive 1xWeek. Again, 5-6 days complicates the schedule for me. Look at my avatar, I'm not too smart.

By the way, your pre-TRT levels were very similar to mine, I was at 492 ng/dL but I felt like crap, probably due to my low FT. If things works out well, I don't mind to be in the 500s with 1xWeek as long as my FT is in range.

I was reading a study recently in which they injected 50, 75, 100 mg T cypionate per week, once a week, subQ, and even though at day 7 TT had fallen to baseline levels, none of the participants had low T symptoms.

At a dose of 75 mg per week, Baseline was around 480s, 6 hours and 24 hours later, TT went up to 650-700, remain around 600 for the rest of the week and fell to 480 on day 7 prior to the injection.

In post hoc analysis, paired comparisons between time points indicated no significant difference among serum total testosterone levels measured 6 hours to 5 days after injection; there was, however, a significant decrease at 7 days, compared both with the initial postinjection measurement (656 6 244 ng/dL and 477 6 185 ng/dL, P = 0.012) and the 5-day measurement (621 6 321 ng/dL and 477 6 185 ng/dL, P = 0.023). Compared with baseline preinjection values, serum concentrations increased significantly at 6 hours after injection for both total testosterone (497 6 140 and 656 6 244, P = 0.02) and free testosterone 118 6 46 pg/mL and 151 6 69 pg/mL, P = 0.003). There was no significant difference in serum levels between the two samples drawn 7 days apart immediately prior to testosterone injections for both total testosterone (497 6 140 and 477 6 185 ng/dL, P = 0.58) and free testosterone (118 6 46 and 107 6 49 pg/mL, P =0.25).

The above supports your "every 5 or 6 days" protocol

That's encouraging. My doctor said that in order to keep HCT down, frequency needed to be increased. I'm glad to see a counter-example.

Good luck mate.

Thanks

<blockquote data-quote="aneuman" data-source="post: 265725" data-attributes="member: 43264">That will be my next step, just need to make sure how my body reacts to different schedules. I tried 3xweek, now 2xweek, my goal is to do it once a week, so I can minimize the number of injections. I don&#039;t mind doing it, but I worry about the next 25 years. Will I still like it?So once I complete 8 weeks on this protocol, and have my labs, I&#039;ll evaluate vs the previous 3xWeek and probably test drive 1xWeek. Again, 5-6 days complicates the schedule for me. Look at my avatar, I&#039;m not too smart.By the way, your pre-TRT levels were very similar to mine, I was at 492 ng/dL but I felt like crap, probably due to my low FT. If things works out well, I don&#039;t mind to be in the 500s with 1xWeek as long as my FT is in range.I was reading a study recently in which they injected 50, 75, 100 mg T cypionate per week, once a week, subQ, and even though at day 7 TT had fallen to baseline levels, none of the participants had low T symptoms.At a dose of 75 mg per week, Baseline was around 480s, 6 hours and 24 hours later, TT went up to 650-700, remain around 600 for the rest of the week and fell to 480 on day 7 prior to the injection. In post hoc analysis, paired comparisons between time points indicated no significant difference among serum total testosterone levels measured 6 hours to 5 days after injection; there was, however, a significant decrease at 7 days, compared both with the initial postinjection measurement (656 6 244 ng/dL and 477 6 185 ng/dL, P = 0.012) and the 5-day measurement (621 6 321 ng/dL and 477 6 185 ng/dL, P = 0.023). Compared with baseline preinjection values, serum concentrations increased significantly at 6 hours after injection for both total testosterone (497 6 140 and 656 6 244, P = 0.02) and free testosterone 118 6 46 pg/mL and 151 6 69 pg/mL, P = 0.003). There was no significant difference in serum levels between the two samples drawn 7 days apart immediately prior to testosterone injections for both total testosterone (497 6 140 and 477 6 185 ng/dL, P = 0.58) and free testosterone (118 6 46 and 107 6 49 pg/mL, P =0.25).The above supports your &quot;every 5 or 6 days&quot; protocolThat&#039;s encouraging. My doctor said that in order to keep HCT down, frequency needed to be increased. I&#039;m glad to see a counter-example. Good luck mate.Thanks</blockquote>

[QUOTE="aneuman, post: 265725, member: 43264"] That will be my next step, just need to make sure how my body reacts to different schedules. I tried 3xweek, now 2xweek, my goal is to do it once a week, so I can minimize the number of injections. I don't mind doing it, but I worry about the next 25 years. Will I still like it? So once I complete 8 weeks on this protocol, and have my labs, I'll evaluate vs the previous 3xWeek and probably test drive 1xWeek. Again, 5-6 days complicates the schedule for me. Look at my avatar, I'm not too smart. By the way, your pre-TRT levels were very similar to mine, I was at 492 ng/dL but I felt like crap, probably due to my low FT. If things works out well, I don't mind to be in the 500s with 1xWeek as long as my FT is in range. I was reading a study recently in which they injected 50, 75, 100 mg T cypionate per week, once a week, subQ, and even though at day 7 TT had fallen to baseline levels, none of the participants had low T symptoms. At a dose of 75 mg per week, Baseline was around 480s, 6 hours and 24 hours later, TT went up to 650-700, remain around 600 for the rest of the week and fell to 480 on day 7 prior to the injection. [B][I]In post hoc analysis, paired comparisons between time points indicated no significant difference among serum total testosterone levels measured 6 hours to 5 days after injection; there was, however, a significant decrease at 7 days, compared both with the initial postinjection measurement (656 6 244 ng/dL and 477 6 185 ng/dL, P = 0.012) and the 5-day measurement (621 6 321 ng/dL and 477 6 185 ng/dL, P = 0.023). Compared with baseline preinjection values, serum concentrations increased significantly at 6 hours after injection for both total testosterone (497 6 140 and 656 6 244, P = 0.02) and free testosterone 118 6 46 pg/mL and 151 6 69 pg/mL, P = 0.003). There was no significant difference in serum levels between the two samples drawn 7 days apart immediately prior to testosterone injections for both total testosterone (497 6 140 and 477 6 185 ng/dL, P = 0.58) and free testosterone (118 6 46 and 107 6 49 pg/mL, P =0.25).[/I][/B] The above supports your "every 5 or 6 days" protocol That's encouraging. My doctor said that in order to keep HCT down, frequency needed to be increased. I'm glad to see a counter-example. Good luck mate. Thanks [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038