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The 5-alpha reductase inhibitory effect is seen even at commonly used doses of 160-320mg, and likely increases in a dose-dependent manner.

A few interesting reads:

http://www.jstage.jst.go.jp/pub/html/AY03S050_en.html;jsessionid=81630A849A7EB84FD9A7F5FA3482C636

"supercritical CO2 extract used in trials (Sabalselect® - a saw palmetto extract) has been tested for its actions on rat 5α-reductase where it was found that two constituent fatty acids, oleic acid and lauric acid, inhibited the activity of this enzyme with IC50 values of 54.3-54.5µg/mL and 66.2-67.6µg/mL respectively
( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002402/ )

An interesting read on plant derived anti-androgens:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/#!po=51.3158

Many don't know that GREEN TEA can actually cause 5-alpha reductase inhibition (i.e. lowering DHT).

<blockquote data-quote="Dr Justin Saya MD" data-source="post: 60614" data-attributes="member: 12687">The 5-alpha reductase inhibitory effect is seen even at commonly used doses of 160-320mg, and likely increases in a dose-dependent manner.A few interesting reads:<a href="http://www.jstage.jst.go.jp/pub/html/AY03S050_en.html;jsessionid=81630A849A7EB84FD9A7F5FA3482C636" target="_blank">http://www.jstage.jst.go.jp/pub/html/AY03S050_en.html;jsessionid=81630A849A7EB84FD9A7F5FA3482C636</a>&quot;supercritical CO2 extract used in trials (Sabalselect® - a saw palmetto extract) has been tested for its actions on rat 5α-reductase where it was found that two constituent fatty acids, oleic acid and lauric acid, inhibited the activity of this enzyme with IC50 values of 54.3-54.5µg/mL and 66.2-67.6µg/mL respectively( <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002402/" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002402/</a> )An interesting read on plant derived anti-androgens:<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/#!po=51.3158" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/#!po=51.3158</a>Many don&#039;t know that GREEN TEA can actually cause 5-alpha reductase inhibition (i.e. lowering DHT).</blockquote>

[QUOTE="Dr Justin Saya MD, post: 60614, member: 12687"] The 5-alpha reductase inhibitory effect is seen even at commonly used doses of 160-320mg, and likely increases in a dose-dependent manner. A few interesting reads: [url]http://www.jstage.jst.go.jp/pub/html/AY03S050_en.html;jsessionid=81630A849A7EB84FD9A7F5FA3482C636[/url] "supercritical CO2 extract used in trials (Sabalselect® - a saw palmetto extract) has been tested for its actions on rat 5α-reductase where it was found that two constituent fatty acids, oleic acid and lauric acid, inhibited the activity of this enzyme with IC50 values of 54.3-54.5µg/mL and 66.2-67.6µg/mL respectively ( [url]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002402/[/url] ) An interesting read on plant derived anti-androgens: [url]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693613/#!po=51.3158[/url] Many don't know that GREEN TEA can actually cause 5-alpha reductase inhibition (i.e. lowering DHT). [/QUOTE]

Verification

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038