Transdermals pose a problem for low SHBG guys. I have SHBG of 16. I started out TRT with T gel applied daily. When I had blood tests 12 hours after applying the gel my Total T level would be around 800. However when I running blood tests 22 hours after applying the gel my Total T would drop to 180.
The late Dr. Crisler said that this was because the T absorbed via the skin goes very quickly to the bloodstream with low SHBG guys like me it's flushed quickly via the urine. He recommended me to switch to bi weekly SUBQ injections, stating the the T is absorbed slower via the SUBQ tissue. I've been doing that for 2 years now and this protocol enabled me to sustain steady and healthy levels of T.
