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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Switching From Daily To EOD or Anything Else
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<blockquote data-quote="Fortunate" data-source="post: 226464" data-attributes="member: 42264"><p>The quote above is something I posted recently. I discovered the source of my bouts of anxiety and felt really compelled to give follow up on this. I was very surprised to discover the culprit: CoQ10 supplements.</p><p></p><p>In addition to low T, I suffer from migraines, and in some ways they are interrelated. There are a number of supplements that are commonly tied to headache reduction, including CoQ10. I recently started taking it on a regular basis. Unfortunately, I can't remember with 100% certainly, but I am nearly certain that I had been taking 200mg a day and forgot about it.</p><p></p><p>Fast forward a month or so. I have been working on titrating my daily microdosing of enanthate and began noticing bouts of anxiety and tachycardia. I felt uncomfortably keyed up, and it always seemed to happen around 12 hours after my injection. Most of us here tend to think that many of our physical and mental problems are related to low T or the treatment of such, including me. I naturally concluded that either T levels or metabolites were peaking at around 12 hours, so I started watching it more closely, and even tried an AI to see what that did to these episodes.</p><p></p><p>On top of the regular, near-daily episodes, I have had some scattered days on which I feel very mentally alert, with tons of energy and clarity. However, many of those days were also associated with horrible nights of insomnia - like the alertness just wouldn't go away, despite a desire to sleep. It wrecked several days for me.</p><p></p><p>While these episodes of evening anxiety and occasional nights of insomnia persisted, I sought ways to combat them. Naturally, I assumed TRT was causing all this. So, I decided try a twice-a-week protocol - thinking maybe that would disrupt the 12 hour pattern. So, I injected Xyosted 50mg one day. Then, around three days later, at the same time in the evening, the episode recurred - anxious, uncomfortable feeling with tachycardia. I was perplexed, because it did not follow the 12 hour rule, and thought it very unlikely to be from the same root cause as the other episodes.</p><p></p><p>So, I started to consider other possible causes, and it occurred to me that shortly before this all started, I increased my CoQ10 dose to 400mg/day, and bam! That was the explanation! As I said above, I am not 100% sure, but am near 100% sure that I had been taking 200mg/day prior to all this. After spotting the correlation, I did a little research and read tons of anecdotes of people feeling improved mental clarity and energy on CoQ10. But, many also reported feeling keyed up and anxious and several reported severe insomnia! I then realized that I tend to take my AM supplements around the same time as my morning injection. The bouts of anxiety were not 12 hours after my injection - they were around 12 hours after taking the high dose CoQ10!</p><p></p><p>I have stated numerous times that I think you have to tread lightly with anecdotal information, but in many situations, it's the best you have. That totally applied in this situation. I stopped the CoQ10, and the 12-hour recurring episodes have totally resolved! I was a bit shocked by all this, but am really glad to have answers. On the flip side, there were days I felt really great on CoQ10 mentally, so I wouldn't rule out trying it at lower doses in the future.</p><p></p><p>This experience has highlighted several lessons for me, including the reaffirmation that low T is not the source of all our ills, nor is TRT the solution for all of them. It also drove home the notion that even over the counter, seemingly innocuous supplements can be powerful. I am fortunate to have figured this out and would encourage us all to take into consideration OTC supplements when trying to troubleshoot some of our struggles. I made a similar discover about DHEA about a year or so ago and don't touch it any more.</p><p></p><p>Many of us blame things like anxiety on either low T, being supraphysiologic, or having high or low E2. This was a eureka moment for me, so I will create a separate thread on this, specifically to take CoQ10 into consideration. It may be useful to generate more discussion on this interesting supplement.</p></blockquote><p></p>
[QUOTE="Fortunate, post: 226464, member: 42264"] The quote above is something I posted recently. I discovered the source of my bouts of anxiety and felt really compelled to give follow up on this. I was very surprised to discover the culprit: CoQ10 supplements. In addition to low T, I suffer from migraines, and in some ways they are interrelated. There are a number of supplements that are commonly tied to headache reduction, including CoQ10. I recently started taking it on a regular basis. Unfortunately, I can't remember with 100% certainly, but I am nearly certain that I had been taking 200mg a day and forgot about it. Fast forward a month or so. I have been working on titrating my daily microdosing of enanthate and began noticing bouts of anxiety and tachycardia. I felt uncomfortably keyed up, and it always seemed to happen around 12 hours after my injection. Most of us here tend to think that many of our physical and mental problems are related to low T or the treatment of such, including me. I naturally concluded that either T levels or metabolites were peaking at around 12 hours, so I started watching it more closely, and even tried an AI to see what that did to these episodes. On top of the regular, near-daily episodes, I have had some scattered days on which I feel very mentally alert, with tons of energy and clarity. However, many of those days were also associated with horrible nights of insomnia - like the alertness just wouldn't go away, despite a desire to sleep. It wrecked several days for me. While these episodes of evening anxiety and occasional nights of insomnia persisted, I sought ways to combat them. Naturally, I assumed TRT was causing all this. So, I decided try a twice-a-week protocol - thinking maybe that would disrupt the 12 hour pattern. So, I injected Xyosted 50mg one day. Then, around three days later, at the same time in the evening, the episode recurred - anxious, uncomfortable feeling with tachycardia. I was perplexed, because it did not follow the 12 hour rule, and thought it very unlikely to be from the same root cause as the other episodes. So, I started to consider other possible causes, and it occurred to me that shortly before this all started, I increased my CoQ10 dose to 400mg/day, and bam! That was the explanation! As I said above, I am not 100% sure, but am near 100% sure that I had been taking 200mg/day prior to all this. After spotting the correlation, I did a little research and read tons of anecdotes of people feeling improved mental clarity and energy on CoQ10. But, many also reported feeling keyed up and anxious and several reported severe insomnia! I then realized that I tend to take my AM supplements around the same time as my morning injection. The bouts of anxiety were not 12 hours after my injection - they were around 12 hours after taking the high dose CoQ10! I have stated numerous times that I think you have to tread lightly with anecdotal information, but in many situations, it's the best you have. That totally applied in this situation. I stopped the CoQ10, and the 12-hour recurring episodes have totally resolved! I was a bit shocked by all this, but am really glad to have answers. On the flip side, there were days I felt really great on CoQ10 mentally, so I wouldn't rule out trying it at lower doses in the future. This experience has highlighted several lessons for me, including the reaffirmation that low T is not the source of all our ills, nor is TRT the solution for all of them. It also drove home the notion that even over the counter, seemingly innocuous supplements can be powerful. I am fortunate to have figured this out and would encourage us all to take into consideration OTC supplements when trying to troubleshoot some of our struggles. I made a similar discover about DHEA about a year or so ago and don't touch it any more. Many of us blame things like anxiety on either low T, being supraphysiologic, or having high or low E2. This was a eureka moment for me, so I will create a separate thread on this, specifically to take CoQ10 into consideration. It may be useful to generate more discussion on this interesting supplement. [/QUOTE]
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