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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Switching From Cream to Injectable T (subQ)
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<blockquote data-quote="madman" data-source="post: 150703" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">high SHBG </span>is a problem and goes hand in hand with <span style="color: rgb(184, 49, 47)">low FT</span></strong></p><p></p><p>- most definitely but you need to understand that ones FT levels not only depend on just ones SHBG level but most importantly what TT levels one has.</p><p></p><p>- in general when one has low TT or sub-par TT levels it is a given that one will have low/sub-par FT levels</p><p></p><p>- in cases of high SHBG most will have a descent TT 600-700 ng/dL but in many cases will have low/sub-par FT and depending on how high SHBG is.....the higher the level the lower one FT will be for the same TT......meaning if you take one man with a TT of 600 ng/dL and SHBG of 50 nmol/L and you compare it to another man with the same TT of 600 ng/dL but a higher SHBG of 90 nmol/L than the latter person will have a lower FT level for the same TT level.</p><p></p><p>If we use the newer calculated method <a href="https://tru-t.org/" target="_blank"><span style="font-size: 18px"><strong>TruT <span style="color: rgb(0, 0, 0)">Free Testosterone Calculator by</span></strong> <span style="color: rgb(184, 49, 47)"><strong>FPT</strong></span></span></a></p><p></p><p></p><p>Than if one had a <strong>TT 600 ng/dL</strong>, <span style="color: rgb(184, 49, 47)"><strong>SHBG 50 nmol/L</strong> </span>and <span style="color: rgb(44, 130, 201)"><strong>Albumin 4.3 g/dL</strong></span> <strong>(<span style="color: rgb(184, 49, 47)">mean</span>)</strong> than <span style="color: rgb(184, 49, 47)"><strong>FT</strong></span> would be <span style="color: rgb(184, 49, 47)"><strong>18.51 ng/dL</strong></span> <strong>(<span style="color: rgb(184, 49, 47)">low end</span> of the reference range <span style="color: rgb(184, 49, 47)">16-31 ng/dL</span>)</strong></p><p>[ATTACH=full]7580[/ATTACH]</p><p></p><p></p><p>If the other person had the same <strong>TT 600 ng/dL</strong>, but a <span style="color: rgb(184, 49, 47)"><strong>higher SHBG 90 nmol/L</strong></span> and <span style="color: rgb(44, 130, 201)"><strong>Albumin 4.3 g/dL</strong></span> than <span style="color: rgb(184, 49, 47)"><strong>FT </strong></span>would be <strong><span style="color: rgb(184, 49, 47)">14.76 ng/dL</span></strong> <strong>(<span style="color: rgb(184, 49, 47)">LOW</span>) reference range <span style="color: rgb(184, 49, 47)">16-31 ng/dL</span></strong></p><p>[ATTACH=full]7582[/ATTACH]</p><p></p><p></p><p>So as you can see even with both men having a descent TT of 600 ng/dL one will have sub-par FT (low end reference range) and the other will have low FT (below reference range).....due to the difference in the SHBG levels (both are high but one is clearly a lot higher) and although there is a big difference in SHBG levels 50/90 nmol/L (40 nmol/L) you will notice that FT levels are not as drastically different 18.51/14.76 ng/dL even though both men have the same descent TT level.....due to <strong><span style="color: rgb(44, 130, 201)">the complex, non-linear allostery in SHBG's association with testosterone.</span></strong></p><p></p><p></p><p>Even with an SHBG of 70,80,90,100 as long as TT is high enough one can have a healthy FT......but even then TT will not need to be as high as we used to think due to <strong><span style="color: rgb(44, 130, 201)">the complex, non-linear allostery in SHBG's association with testosterone.</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 150703, member: 13851"] [B][COLOR=rgb(184, 49, 47)]high SHBG [/COLOR]is a problem and goes hand in hand with [COLOR=rgb(184, 49, 47)]low FT[/COLOR][/B] - most definitely but you need to understand that ones FT levels not only depend on just ones SHBG level but most importantly what TT levels one has. - in general when one has low TT or sub-par TT levels it is a given that one will have low/sub-par FT levels - in cases of high SHBG most will have a descent TT 600-700 ng/dL but in many cases will have low/sub-par FT and depending on how high SHBG is.....the higher the level the lower one FT will be for the same TT......meaning if you take one man with a TT of 600 ng/dL and SHBG of 50 nmol/L and you compare it to another man with the same TT of 600 ng/dL but a higher SHBG of 90 nmol/L than the latter person will have a lower FT level for the same TT level. If we use the newer calculated method [URL='https://tru-t.org/'][SIZE=18px][B]TruT [COLOR=rgb(0, 0, 0)]Free Testosterone Calculator by[/COLOR][/B] [COLOR=rgb(184, 49, 47)][B]FPT[/B][/COLOR][/SIZE][/URL] Than if one had a [B]TT 600 ng/dL[/B], [COLOR=rgb(184, 49, 47)][B]SHBG 50 nmol/L[/B] [/COLOR]and [COLOR=rgb(44, 130, 201)][B]Albumin 4.3 g/dL[/B][/COLOR] [B]([COLOR=rgb(184, 49, 47)]mean[/COLOR])[/B] than [COLOR=rgb(184, 49, 47)][B]FT[/B][/COLOR] would be [COLOR=rgb(184, 49, 47)][B]18.51 ng/dL[/B][/COLOR] [B]([COLOR=rgb(184, 49, 47)]low end[/COLOR] of the reference range [COLOR=rgb(184, 49, 47)]16-31 ng/dL[/COLOR])[/B] [ATTACH=full]7580[/ATTACH] If the other person had the same [B]TT 600 ng/dL[/B], but a [COLOR=rgb(184, 49, 47)][B]higher SHBG 90 nmol/L[/B][/COLOR] and [COLOR=rgb(44, 130, 201)][B]Albumin 4.3 g/dL[/B][/COLOR] than [COLOR=rgb(184, 49, 47)][B]FT [/B][/COLOR]would be [B][COLOR=rgb(184, 49, 47)]14.76 ng/dL[/COLOR][/B] [B]([COLOR=rgb(184, 49, 47)]LOW[/COLOR]) reference range [COLOR=rgb(184, 49, 47)]16-31 ng/dL[/COLOR][/B] [ATTACH=full]7582[/ATTACH] So as you can see even with both men having a descent TT of 600 ng/dL one will have sub-par FT (low end reference range) and the other will have low FT (below reference range).....due to the difference in the SHBG levels (both are high but one is clearly a lot higher) and although there is a big difference in SHBG levels 50/90 nmol/L (40 nmol/L) you will notice that FT levels are not as drastically different 18.51/14.76 ng/dL even though both men have the same descent TT level.....due to [B][COLOR=rgb(44, 130, 201)]the complex, non-linear allostery in SHBG's association with testosterone.[/COLOR][/B] Even with an SHBG of 70,80,90,100 as long as TT is high enough one can have a healthy FT......but even then TT will not need to be as high as we used to think due to [B][COLOR=rgb(44, 130, 201)]the complex, non-linear allostery in SHBG's association with testosterone.[/COLOR][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Switching From Cream to Injectable T (subQ)
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