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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE OVER 13 YEARS
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<blockquote data-quote="madman" data-source="post: 222693" data-attributes="member: 13851"><p><strong>SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE THERAPY (TTH) OVER 13 YEARS IN MEN WITH FUNCTIONAL HYPOGONADISM (2022)</strong></p><p><em>Farid Saad1,2, Ahmad Haider, Karim Haider, Gheorghe Doros, Abdulmaged Traish Consultant, Bayer AG, Berlin, Germany; Research Department, Guld Medical University, Ajman, UAE Private Urology Practice, Bremerhaven, Germany; Department of Epidemiology and Statistics, Boston University School of Public Health, Boston, MA, USA; Department of Biochemistry and Department of Urology, Boston University School of Medicine, Boston, MA, USA</em></p><p></p><p></p><p><strong>Introduction:</strong> <em>Studies reported inconsistent effects of TTh on the lipid profile in men with hypogonadism. </em></p><p></p><p><strong>Methods</strong><em>: In a registry of 797 men with symptomatic functional hypogonadism, 394 men (49.5%) received TTh by testosterone undecanoate (TU) injections 1000mg/12weeks following an initial 6-week interval (T-group). 402 men opted against TTh and served as controls (CTRL). 13-year data are presented. Means and standard deviations of absolute measures over 13 years are reported. </em></p><p></p><p><strong>Results:</strong> <em>Mean age at baseline: 58.5±6.3 (T-group), 63.2±4.8 (CTRL). Mean (median) follow-up: T-group 10.1±3.0(11), CTRL 10.5±3.0(12) years.</em></p><p><em></em></p><p><em></em></p><p><em><strong>*<u>Total cholesterol</u> (TC) (mmol/L for all lipids) decreased from 8.0±1.1 to 5.1±0.3 (T-group) and increased from 6.6±1.3 to 8.0±1.3 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>HDL</u> increased from 1.0±0.3 to 1.6±0.3 (T-group) and decreased from 1.2±0.5 to 0.9±0.4 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The <u>TC: HDL ratio</u> decreased from 9.1±3.6 to 3.3±0.6 (T-group) and increased from 6.5±3.4 to 11.4±5.6 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>LDL</u> decreased from 4.4±0.9 to 2.5±0.3 (T-group) and increased from 3.5±1.3 to 4.6±1.5 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>Triglycerides</u> (TG) decreased from 3.2±0.6 to 2.2±0.1 (T-group) and increased from 3.0±0.5 to 3.7±0.6 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The <u>LDL: HDL ratio</u> decreased from 5.1±2.5 to 1.7±0.4 (T-group) and increased from 3.6±2.6 to 6.8±4.5 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The <u>HDL:LDL ratio</u> increased from 0.24±0.10 to 0.64±0.13 (T-group) and decreased from 0.41±0.22 to 0.22±0.13 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>Non-HDL</u> decreased from 7.0±1.0 to 3.5±0.3 (T-group) and increased from 5.4±1.4 to 7.2±1.4 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<u>Remnant cholesterol</u> decreased from 2.6±0.9 to 1.0±0.3 (T-group) and increased from 1.9±0.9 to 2.6±0.8 (CTRL) (p<0.0001 for both). </strong></em></p><p><em><strong></strong></em></p><p><em><strong>*The <u>TG: HDL ratio</u> decreased from 8.4±3.7 to 3.2±0.6 (T-group) and increased from 6.7±3.5 to 11.7±5.7 (CTRL) (p<0.0001 for both).</strong></em></p><p></p><p></p><p></p><p></p><p><strong>Conclusion: </strong><em><strong>Long-term treatment with TU in men with functional hypogonadism improved the lipid profile, which worsened in controls.</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 222693, member: 13851"] [B]SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE THERAPY (TTH) OVER 13 YEARS IN MEN WITH FUNCTIONAL HYPOGONADISM (2022)[/B] [I]Farid Saad1,2, Ahmad Haider, Karim Haider, Gheorghe Doros, Abdulmaged Traish Consultant, Bayer AG, Berlin, Germany; Research Department, Guld Medical University, Ajman, UAE Private Urology Practice, Bremerhaven, Germany; Department of Epidemiology and Statistics, Boston University School of Public Health, Boston, MA, USA; Department of Biochemistry and Department of Urology, Boston University School of Medicine, Boston, MA, USA[/I] [B]Introduction:[/B] [I]Studies reported inconsistent effects of TTh on the lipid profile in men with hypogonadism. [/I] [B]Methods[/B][I]: In a registry of 797 men with symptomatic functional hypogonadism, 394 men (49.5%) received TTh by testosterone undecanoate (TU) injections 1000mg/12weeks following an initial 6-week interval (T-group). 402 men opted against TTh and served as controls (CTRL). 13-year data are presented. Means and standard deviations of absolute measures over 13 years are reported. [/I] [B]Results:[/B] [I]Mean age at baseline: 58.5±6.3 (T-group), 63.2±4.8 (CTRL). Mean (median) follow-up: T-group 10.1±3.0(11), CTRL 10.5±3.0(12) years. [B]*[U]Total cholesterol[/U] (TC) (mmol/L for all lipids) decreased from 8.0±1.1 to 5.1±0.3 (T-group) and increased from 6.6±1.3 to 8.0±1.3 (CTRL) (p<0.0001 for both). *[U]HDL[/U] increased from 1.0±0.3 to 1.6±0.3 (T-group) and decreased from 1.2±0.5 to 0.9±0.4 (CTRL) (p<0.0001 for both). *The [U]TC: HDL ratio[/U] decreased from 9.1±3.6 to 3.3±0.6 (T-group) and increased from 6.5±3.4 to 11.4±5.6 (CTRL) (p<0.0001 for both). *[U]LDL[/U] decreased from 4.4±0.9 to 2.5±0.3 (T-group) and increased from 3.5±1.3 to 4.6±1.5 (CTRL) (p<0.0001 for both). *[U]Triglycerides[/U] (TG) decreased from 3.2±0.6 to 2.2±0.1 (T-group) and increased from 3.0±0.5 to 3.7±0.6 (CTRL) (p<0.0001 for both). *The [U]LDL: HDL ratio[/U] decreased from 5.1±2.5 to 1.7±0.4 (T-group) and increased from 3.6±2.6 to 6.8±4.5 (CTRL) (p<0.0001 for both). *The [U]HDL:LDL ratio[/U] increased from 0.24±0.10 to 0.64±0.13 (T-group) and decreased from 0.41±0.22 to 0.22±0.13 (CTRL) (p<0.0001 for both). *[U]Non-HDL[/U] decreased from 7.0±1.0 to 3.5±0.3 (T-group) and increased from 5.4±1.4 to 7.2±1.4 (CTRL) (p<0.0001 for both). *[U]Remnant cholesterol[/U] decreased from 2.6±0.9 to 1.0±0.3 (T-group) and increased from 1.9±0.9 to 2.6±0.8 (CTRL) (p<0.0001 for both). *The [U]TG: HDL ratio[/U] decreased from 8.4±3.7 to 3.2±0.6 (T-group) and increased from 6.7±3.5 to 11.7±5.7 (CTRL) (p<0.0001 for both).[/B][/I] [B]Conclusion: [/B][I][B]Long-term treatment with TU in men with functional hypogonadism improved the lipid profile, which worsened in controls.[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
SUSTAINED IMPROVEMENT OF LIPID PATTERN AS A RESULT OF LONG-TERM TESTOSTERONE OVER 13 YEARS
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