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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Surgery as a first-line option for prolactinomas
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<blockquote data-quote="madman" data-source="post: 238230" data-attributes="member: 13851"><p><strong><u>Article highlights </u></strong></p><p></p><p><em><strong>● Dopamine agonists are established first-line therapy for the treatment of prolactinomas </strong></em></p><p><em><strong></strong></em></p><p><em><strong>● <em>Prolactin levels are normalized in 73–96% of patients treated with dopamine agonists, and tumor shrinkage is observed in 47–97% </em></strong></em></p><p><em><strong></strong></em></p><p><em><strong>● Long-term dopamine agonist withdrawal after prolactin normalization is accomplished in only 16–21% of patients, often leading to protracted or even life-long use </strong></em></p><p><em><strong></strong></em></p><p><em><strong>● Transsphenoidal surgical cure rates for microadenomas range from approximately 65–93% (up to 100% in some reports), and for macroadenomas approximately 45–60%, with patients in both groups who were not cured requiring less DA to achieve long-term remission </strong></em></p><p><em><strong></strong></em></p><p><em><strong>● Transsphenoidal surgery for prolactinoma is very safe, with new hormonal deficiencies reported in less than 3% of patients, and major morbidity and mortality below 1% </strong></em></p><p><em><strong></strong></em></p><p><em><strong>● Extent of cavernous sinus invasion, not tumor size, is the single most important independent primary predictor of surgical remission, with high rates of remission in tumors with low-grade cavernous sinus invasion </strong></em></p><p></p><p><strong><em>● Transsphenoidal surgery may be a more cost-effective, easier, and equally effective treatment for prolactinomas without cavernous sinus invasion. It should be considered a first-line treatment in appropriate situations and when expert pituitary surgery is available</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 238230, member: 13851"] [B][U]Article highlights [/U][/B] [I][B]● Dopamine agonists are established first-line therapy for the treatment of prolactinomas ● [I]Prolactin levels are normalized in 73–96% of patients treated with dopamine agonists, and tumor shrinkage is observed in 47–97% [/I] ● Long-term dopamine agonist withdrawal after prolactin normalization is accomplished in only 16–21% of patients, often leading to protracted or even life-long use ● Transsphenoidal surgical cure rates for microadenomas range from approximately 65–93% (up to 100% in some reports), and for macroadenomas approximately 45–60%, with patients in both groups who were not cured requiring less DA to achieve long-term remission ● Transsphenoidal surgery for prolactinoma is very safe, with new hormonal deficiencies reported in less than 3% of patients, and major morbidity and mortality below 1% ● Extent of cavernous sinus invasion, not tumor size, is the single most important independent primary predictor of surgical remission, with high rates of remission in tumors with low-grade cavernous sinus invasion [/B][/I] [B][I]● Transsphenoidal surgery may be a more cost-effective, easier, and equally effective treatment for prolactinomas without cavernous sinus invasion. It should be considered a first-line treatment in appropriate situations and when expert pituitary surgery is available[/I][/B] [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Surgery as a first-line option for prolactinomas
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