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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
sulphorophane for cancer and longer healthspan
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<blockquote data-quote="Vince" data-source="post: 197342" data-attributes="member: 843"><p>Open-access full-text is available for these papers:</p><p></p><p>PB: <a href="https://www.tandfonline.com/doi/full/10.3109/13880209.2016.1138314" target="_blank">Protective role of sulphoraphane against vascular complications in diabetes</a></p><p></p><p>JCCS: <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842175/" target="_blank">The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review</a></p><p></p><p>The PB paper is a meta:</p><p><em>"In this review, literature searches were undertaken in Medline and in CrossRef. Non-English language articles were excluded. Keywords [sulphoraphane and (diabetes, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, diabetic complications, vascular, cardiomyocytes, heart or glycation)] have been used to select the articles."</em></p><p>So in addition to the limitations of being a meta, and the narrow search, these aren’t just populations on standard diets — they already have diabetes. That leaves me puzzling about incremental benefit for healthy people on enlightened ancestral diets.</p><p></p><p>The JCCS paper is just a mini-review. My main concern with it is what base of cancer etiology it’s attempting to build on. It leads right off by genuflecting to somatic dogma:</p><p><em>"The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory genes of the cell."</em></p><p>If cancer is a metabolic mitochondrial disease, insight here might be limited. The biochemistry is presumably based on people on standard diets. There’s no mention of Warburg or Seyfried in the paper.</p></blockquote><p></p>
[QUOTE="Vince, post: 197342, member: 843"] Open-access full-text is available for these papers: PB: [URL='https://www.tandfonline.com/doi/full/10.3109/13880209.2016.1138314']Protective role of sulphoraphane against vascular complications in diabetes[/URL] JCCS: [URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842175/']The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review[/URL] The PB paper is a meta: [I]"In this review, literature searches were undertaken in Medline and in CrossRef. Non-English language articles were excluded. Keywords [sulphoraphane and (diabetes, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy, diabetic complications, vascular, cardiomyocytes, heart or glycation)] have been used to select the articles."[/I] So in addition to the limitations of being a meta, and the narrow search, these aren’t just populations on standard diets — they already have diabetes. That leaves me puzzling about incremental benefit for healthy people on enlightened ancestral diets. The JCCS paper is just a mini-review. My main concern with it is what base of cancer etiology it’s attempting to build on. It leads right off by genuflecting to somatic dogma: [I]"The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory genes of the cell."[/I] If cancer is a metabolic mitochondrial disease, insight here might be limited. The biochemistry is presumably based on people on standard diets. There’s no mention of Warburg or Seyfried in the paper. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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sulphorophane for cancer and longer healthspan
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