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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Sugar Intake Reduces Testosterone Blood Levels
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<blockquote data-quote="Nelson Vergel" data-source="post: 183816" data-attributes="member: 3"><p><strong>Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism</strong></p><p>Caronia, Lisa M ; Dwyer, Andrew A ; Hayden, Douglas ; Amati, Francesca ; Pitteloud, Nelly ; Hayes, Frances J</p><p>Clinical endocrinology (Oxford), 2013, Vol.78 (2), p.291-296</p><p></p><p>Design</p><p>Cross‐sectional study.</p><p></p><p>Patients and Methods</p><p>74 men (19–74 years, mean 51·4 ± 1·4 years) underwent a standard 75‐g oral glucose tolerance test with blood sampling at 0, 30, 60, 90 and 120 min. Fasting serum glucose, insulin, total T (and calculated free T ), LH , SHBG , leptin and cortisol were measured.</p><p></p><p>Results</p><p>57% of the men had normal GT , 30% had impaired GT and 13% had newly diagnosed type 2 diabetes. Glucose ingestion was associated with a 25% decrease in mean T levels (delta = −4·2 ± 0·3 nm , P < 0·0001). T levels remained suppressed at 120 min compared with baseline (13·7 ± 0·6 vs 16·5 ± 0·7 nm , P < 0·0001) and did not differ across GT or BMI . Of the 66 men with normal T levels at baseline, 10 (15%) had levels that decreased to the hypogonadal range (<9·7 nm ) at one or more time points. SHBG , LH and cortisol levels were unchanged. Leptin levels decreased from baseline at all time points (P < 0·0001).</p><p></p><p>Conclusions</p><p>Glucose ingestion induces a significant reduction in total and free T levels in men, which is similar across the spectrum of glucose tolerance. This decrease in T appears to be because of a direct testicular defect, but the absence of compensatory changes in LH suggests an additional central component. Men found to have low nonfasting T levels should be re‐evaluated in the fasting state.</p><p></p><p></p><p></p><p></p><p><strong><a href="https://thslc-houston.primo.exlibrisgroup.com/discovery/fulldisplay?docid=cdi_doaj_primary_oai_doaj_org_article_4bfbafc6eae44574808aeff2623e98db&context=PC&vid=01TEXASHEALTH_HOUSTON:TMC_INST&lang=en&adaptor=Primo%20Central&tab=Everything" target="_blank">Sugar-sweetened beverage intake and serum testosterone levels in adult males 20–39 years old in the United States</a></strong></p><p>Chen, Liang ; Xie, Yu-Mei ; Pei, Jian-Hao ; Kuang, Jian ; Chen, Hong-Mei ; Chen, Zhong ; Li, Zhong-Wen ; Fu, Xiao-Ying ; Wang, Long ; Lai, Shui-Qing ; Zhang, Shu-Ting ; Chen, Zhi-Jiang ; Lin, Jin-xin</p><p>Reproductive biology and endocrinology, 2018, Vol.16 (1), p.61-7</p><p></p><p></p><p>This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20-39 years old. All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity. Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m had a higher risk of having a low testosterone level than those with BMI < 25 kg/m (aOR = 3.68, p = 0.044). SSB consumption is significantly associated with low serum testosterone in men 20-39 years old in the United States.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 183816, member: 3"] [B]Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism[/B] Caronia, Lisa M ; Dwyer, Andrew A ; Hayden, Douglas ; Amati, Francesca ; Pitteloud, Nelly ; Hayes, Frances J Clinical endocrinology (Oxford), 2013, Vol.78 (2), p.291-296 Design Cross‐sectional study. Patients and Methods 74 men (19–74 years, mean 51·4 ± 1·4 years) underwent a standard 75‐g oral glucose tolerance test with blood sampling at 0, 30, 60, 90 and 120 min. Fasting serum glucose, insulin, total T (and calculated free T ), LH , SHBG , leptin and cortisol were measured. Results 57% of the men had normal GT , 30% had impaired GT and 13% had newly diagnosed type 2 diabetes. Glucose ingestion was associated with a 25% decrease in mean T levels (delta = −4·2 ± 0·3 nm , P < 0·0001). T levels remained suppressed at 120 min compared with baseline (13·7 ± 0·6 vs 16·5 ± 0·7 nm , P < 0·0001) and did not differ across GT or BMI . Of the 66 men with normal T levels at baseline, 10 (15%) had levels that decreased to the hypogonadal range (<9·7 nm ) at one or more time points. SHBG , LH and cortisol levels were unchanged. Leptin levels decreased from baseline at all time points (P < 0·0001). Conclusions Glucose ingestion induces a significant reduction in total and free T levels in men, which is similar across the spectrum of glucose tolerance. This decrease in T appears to be because of a direct testicular defect, but the absence of compensatory changes in LH suggests an additional central component. Men found to have low nonfasting T levels should be re‐evaluated in the fasting state. [B][URL='https://thslc-houston.primo.exlibrisgroup.com/discovery/fulldisplay?docid=cdi_doaj_primary_oai_doaj_org_article_4bfbafc6eae44574808aeff2623e98db&context=PC&vid=01TEXASHEALTH_HOUSTON:TMC_INST&lang=en&adaptor=Primo%20Central&tab=Everything']Sugar-sweetened beverage intake and serum testosterone levels in adult males 20–39 years old in the United States[/URL][/B] Chen, Liang ; Xie, Yu-Mei ; Pei, Jian-Hao ; Kuang, Jian ; Chen, Hong-Mei ; Chen, Zhong ; Li, Zhong-Wen ; Fu, Xiao-Ying ; Wang, Long ; Lai, Shui-Qing ; Zhang, Shu-Ting ; Chen, Zhi-Jiang ; Lin, Jin-xin Reproductive biology and endocrinology, 2018, Vol.16 (1), p.61-7 This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20-39 years old. All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity. Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m had a higher risk of having a low testosterone level than those with BMI < 25 kg/m (aOR = 3.68, p = 0.044). SSB consumption is significantly associated with low serum testosterone in men 20-39 years old in the United States. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Sugar Intake Reduces Testosterone Blood Levels
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